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Development Status

US Previously Marketed

16

Possibly Marketed Outside US

1

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Primary Target

Alanine aminotransferase 1

16

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

16

reactive oxygen species metabolic process

16

Apoptosis

1

Mitogen-activated protein kinase 1 and 3 (ERK2 and ERK1)

1

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Highest Phase

Approved

16

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Approval Year

1921

16

2021

1

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Condition

Autoimmune hepatitis

16

Cardiomyopathy

16

Chronic hepatitis C

16

Erythema

16

Hepatitis B

16

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Treatment Modality

Primary

17

Palliative

16

Preventing

16

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CNS Activity

CNS Non-penetrant

1

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Originator

Benedicenti, A.|Condo-Vissicchio, G

1

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Substance Class

Chemical

17

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Code System

CAS

17

FDA UNII

17

PUBCHEM

17

EPA CompTox

13

SMS_ID

11

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ATC Level 1

ALIMENTARY TRACT AND METABOLISM

1

DERMATOLOGICALS

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ATC Level 2

BILE AND LIVER THERAPY

1

PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS

1

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ATC Level 3

CICATRIZANTS

1

LIVER THERAPY, LIPOTROPICS

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ATC Level 4

Liver therapy

1

Other cicatrizants

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Substance Form

Salts, Hydrates, Esters, etc.

15

Principal Form

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Showing 1 - 10 of 17 results

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ENOXOLONE

P540XA09DR

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

ALOE EMODIN

C8IYT9CR7C

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Status:

Possibly Marketed Outside US

First approved in 2021

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Protein kinase C (PKC)

Mitogen-activated protein kinase 1 and 3 (ERK2 and ERK1)

Conditions:

Lymphocytic leukemia

Aloe emodin is a hydroxyanthraquinone found in Aloe vera leaves. It plays an important role in the regulation of cell growth and death. It has been reported to promote the anti-cancer effects in various cancer cells by inducing apoptosis. Aloe emodin...

selectively inhibits human neuroectodermal tumor cell growth in tissue cultures and in animal models. It has significant antileukemic activity against the P-388 lymphocytic leukemia in mice. Anti-glioma action of Aloe emodin involves ERK-independent induction of both apoptosis and autophagy, as well as ERK inhibition-mediated differentiation of glioma cells. Aloe-emodin can not pass through the blood-brain barrier.

POTASSIUM GLYCYRRHETINATE

5850KHR68O

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

MAGNESIUM GLYCYRRHIZINATE

4U2UBI61D7

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

ENOXOLONE SODIUM

E15REE98CW

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

AMMONIUM GLYCYRRHIZINATE TRIHYDRATE

78NEL3149I

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

MONOPOTASSIUM GLYCYRRHIZINATE

T8XVV1JDN8

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

ENOXOLONE DIPOTASSIUM

ZJI2YIM6Z9

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

MONOSODIUM GLYCYRRHIZINATE

V4B3392JBL

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

DIAMMONIUM GLYCYRRHIZINATE

A9ZZD585U6

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Status:

US Previously Marketed

First marketed in 1921

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Alanine aminotransferase 1

reactive oxygen species metabolic process

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Conditions:

Radiodermatitis

Autoimmune hepatitis

Chronic hepatitis C

Chronic hepatitis C

Autoimmune hepatitis

Glycyrrhizic Acid is specific compound isolated from licorice plants. Ammonium Glycyrrhizate (also known as GLYCYRRHIZIN, AMMONIATED) is a salt, was investigated to be a safe and is used as ingredient in the formulation of makeup, fragrance, hair car...

e, skin care, shaving, personal hygiene and suntan products.

Showing 1 - 10 of 17 results

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