BEREFRINE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C14H21NO2
Molecular Weight	235.322
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C[C@H](OC1C(C)(C)C)C2=CC(O)=CC=C2

InChI

InChIKey=ORIOFGXXYYXLNY-UEWDXFNNSA-N

InChI=1S/C14H21NO2/c1-14(2,3)13-15(4)9-12(17-13)10-6-5-7-11(16)8-10/h5-8,12-13,16H,9H2,1-4H3/t12-,13?/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/?2008281 | https://www.ncbi.nlm.nih.gov/pubmed/8272415

Berefrine (also known as phenylephrine oxazolidine), a prodrug of phenylephrine, is a mydriatic agent. Berefrine was developed for improving ocular absorption and reducing systemic side effects.

Approval Year

PubMed

Title	Date	PubMed
Ocular pharmacokinetics and pharmacodynamics of phenylephrine and phenylephrine oxazolidine in rabbit eyes.	1990 May	2367315
Phenylephrine prodrug. Report of clinical trials.	1991 Feb	2008281

Name

Type

Language

BEREFRINE

Official Name

English

PHENOL, 3-(2-(1,1-DIMETHYLETHYL)-3-METHYL-5-OXAZOLIDINYL)-

Systematic Name

English

berefrine [INN]

Common Name

English

M-((2R,5R)-2-TERT-BUTYL-3-METHYL-5-OXAZOLIDINYL)PHENOL MIXTURE WITH M-((2S,5R)-2-TERT-BUTYL-3-METHYL-5-OXAZOLIDINYL)PHENOL

Common Name

English

BEREFRINE [USAN]

Common Name

English

3-((5R)-2-TERT-BUTYL-3-METHYL-1,3-OXAZOLIDIN-5-YL)PHENOL

Systematic Name

English

2-T-BUTYL-3-METHYL-5-(M-HYDROXYPHENYL)-1,3-OXAZOLIDINE

Systematic Name

English

BUREFRINE

Common Name

English

Code System Code Type Description

WIKIPEDIA

Berefrine