Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2Al.3O4S.H2O |
| Molecular Weight | 360.166 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O
InChI
InChIKey=BUACSMWVFUNQET-UHFFFAOYSA-H
InChI=1S/2Al.3H2O4S.H2O/c;;3*1-5(2,3)4;/h;;3*(H2,1,2,3,4);1H2/q2*+3;;;;/p-6
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Curator's Comment: Description was created based on several sources, including
https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html
Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate.
The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2364031 |
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Target ID: GO:0042310 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | DOMEBORO Approved UseTemporarily relieves minor skin irritations due to:
– Poison ivy | – Poison oak
– Poison sumac | – Insect bites
– Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry |
|||
| Curative | DOMEBORO Approved UseThis medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Molecular basis of carcinogenicity of tungsten alloy particles. | 2015-03-15 |
|
| 1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt. | 2014-03-25 |
|
| Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents. | 2013-11 |
|
| Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine. | 2007-10 |
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| Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. | 2007-10 |
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| Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet. | 2007-09-18 |
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| Ototoxic effect of Burow solution applied to the guinea pig middle ear. | 2007-08 |
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| Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents. | 2006-11 |
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| Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. | 2006-11 |
|
| Aluminum and Alzheimer's disease: a new look. | 2006-11 |
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| The role of aluminum and copper on neuroinflammation and Alzheimer's disease. | 2006-11 |
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| Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease. | 2006-11 |
|
| Some aspects of astroglial functions and aluminum implications for neurodegeneration. | 2006-08-30 |
|
| Aluminum and Alzheimer's disease, a personal perspective after 25 years. | 2006 |
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| Aluminum: new recognition of an old problem. | 2005-12 |
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| Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases. | 2005-11 |
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| [Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method]. | 2004-11 |
|
| The role of metals in neurodegenerative processes: aluminum, manganese, and zinc. | 2003-11-15 |
|
| Aluminum inclusion macrophagic myofasciitis: a recently identified condition. | 2003-11 |
|
| Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain. | 2003-09-15 |
|
| Parenteral nutrition-associated cholestasis in neonates: the role of aluminum. | 2003-09 |
|
| Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite. | 2003 |
|
| Aluminum as a toxicant. | 2002-08 |
|
| Fluoride plus aluminum: useful tools in laboratory investigations, but messengers of false information. | 2002 |
|
| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999-05 |
|
| The antibacterial activity of acetic acid and Burow's solution as topical otological preparations. | 1998-10 |
|
| The ineffectiveness of aluminum subacetate in rheumatoid arthritis. | 1948-04-08 |
Sample Use Guides
DOMEBORO® SOOTHING SOAK
– dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water
– stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use
For use as a soak:
– soak affected area for 15 to 30 minutes as needed, or as directed by a doctor
– repeat 3 times a day or as directed by a doctor
– discard solution after each use.
For use as a compress or wet dressing:
– soak a clean, soft cloth in the solution.
– apply cloth loosely to affected area for 15 to 30 minutes
– repeat as needed or as directed by a doctor
– discard solution after each use
Route of Administration:
Topical
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EPA PESTICIDE CODE |
13906
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CFR |
21 CFR 347.12
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C45678
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CONCEPT | Industrial Aid | ||
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3080712
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C75770
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DTXSID70170784
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17621
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34S289N54E
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C041524
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ALUMINIUM SULFATE
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74768
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1017364
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SUB11702MIG
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17927-65-0
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DB11239
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ALUMINUM SULFATE
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PRIMARY | Description: Colourless, lustrous crystals or crystalline masses, or a white, crystalline powder; odourless. Solubility: Soluble in cold water; freely soluble in hot water; practically insoluble in ethanol (~750 g/l) TS. Category: Astringent drug; used in the preparation of aluminium acetate solution. Storage: Aluminium sulfate should be kept in a well-closed container.Aluminium sulfate contains a variable quantity of water of crystallization. Requirement: Aluminium sulfate contains not less than 51.0% and not more than the equivalent of 59.0% of Al2(SO4)3. | ||
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34S289N54E
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
