HOQUIZIL

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H26N4O5
Molecular Weight	390.4335
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of HOQUIZIL

Structure Search

SMILES

COC1=CC2=C(C=C1OC)C(=NC=N2)N3CCN(CC3)C(=O)OCC(C)(C)O

InChI

InChIKey=YRTMGQYDLITGNA-UHFFFAOYSA-N

InChI=1S/C19H26N4O5/c1-19(2,25)11-28-18(24)23-7-5-22(6-8-23)17-13-9-15(26-3)16(27-4)10-14(13)20-12-21-17/h9-10,12,25H,5-8,11H2,1-4H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4912116 | https://www.ncbi.nlm.nih.gov/pubmed/6276530

Hoquizil, a phosphodiesterase inhibitor, was used as a bronchodilator agent. Information about the current use of this drug is not available.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
phosphoric diester hydrolase activity 4 Target ID: GO:0008081 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6276530	Inhibitor 8297

PubMed

PubMed

Title	Date	PubMed
Hoquizil--a new oral bronchodilator. A double-blind, randomized, coded clinical study using body plethysmography.	1969	4912116
Quinazolines in man. Metabolism and preliminary evaluation of piquizil and hoquizil, two bronchodilators.	1971	4946165
Heterogeneity of biochemical actions among vasodilators.	1982 Jan	6276530

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

Name

Type

Language

HOQUIZIL

Official Name

English

hoquizil [INN]

Common Name

English

2-HYDROXY-2-METHYLPROPYL 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-1-PIPERAZINECARBOXYLATE

Systematic Name

English

1-PIPERAZINECARBOXYLIC ACID, 4-(6,7-DIMETHOXY-4-QUINAZOLINYL)-, 2-HYDROXY-2-METHYLPROPYL ESTER

Common Name

English

Code System Code Type Description

CAS

21560-59-8

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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EVMPD

SUB08056MIG

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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INN

2634

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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FDA UNII

2MP2H1GQ03

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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EPA CompTox

DTXSID30175896

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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SMS_ID

100000084191

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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NCI_THESAURUS

C166582

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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ChEMBL

CHEMBL2110858

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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PUBCHEM

30690

Created by admin on Sat Dec 16 16:16:48 GMT 2023 , Edited by admin on Sat Dec 16 16:16:48 GMT 2023

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ACTIVE MOIETY


					2MP2H1GQ03

HOQUIZIL

SALT/SOLVATE (PARENT)


					9I598ZX18I

HOQUIZIL HYDROCHLORIDE