DIBROMPROPAMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H18Br2N4O2
Molecular Weight	470.158
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)C1=CC(Br)=C(OCCCOC2=C(Br)C=C(C=C2)C(N)=N)C=C1

InChI

InChIKey=GMJFVGRUYJHMCO-UHFFFAOYSA-N

InChI=1S/C17H18Br2N4O2/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4358232
Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf

Dibrompropamidine isetionate is an antiseptic. Ointment containing dibrompropamidine isetionate is used to treat minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
http://purl.obolibrary.org/obo/OMIT_0002795 3 Target ID: http://purl.obolibrary.org/obo/OMIT_0002795 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7996383 \| https://www.ncbi.nlm.nih.gov/pubmed/8229701 \| https://www.ncbi.nlm.nih.gov/pubmed/4358232	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Eye infections 13 Sources: http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf http://www.chemist.net/class/download.class.php?fileName=../sysimages/Brolene_Ointment_ds2355_1.pdf	Curative		Approved 8429	BROLENE Approved Use Dibrompropamidine isetionate is used for minor infections of the eye or eyelid.

PubMed

Title	Date	PubMed
In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.	2001	11822222
Acanthamoeba keratitis: 2007: a train wreck in slow motion.	2007 Sep	17873621
[When the treatment is the problem].	2009 Feb 12	19230298
Cosmetic contact lens-related Acanthamoeba keratitis.	2009 May	19594573

Sample Use Guides

In Vivo Use Guide

Eye ointment containing dibrompropamidine isethionate 0.15% w/w to the affected eye once or twice each day for at least 2 days

Route of Administration: Topical

In Vitro Use Guide

Dibrompropamidine isethionate, 300 μg/ml in aqueous solution was rapidly bactericidal, killing 99.9% of E. coli 15 TAU cells in 3 min.

Name

Type

Language

DIBROMPROPAMIDINE

Official Name

English

4,4'-(TRIMETHYLENEDIOXY)BIS(3-BROMOBENZAMIDINE)

Systematic Name

English

dibrompropamidine [INN]

Common Name

English

DIBROMOPROPAMIDINE [MI]

Common Name

English

DIBROMOPROPAMIDINE

Common Name

English

Dibrompropamidine [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QS01AX14