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Details

Stereochemistry ACHIRAL
Molecular Formula C17H18Br2N4O2.2C2H6O4S
Molecular Weight 722.422
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIBROMPROPAMIDINE ISETHIONATE

SMILES

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)C1=CC=C(OCCCOC2=C(Br)C=C(C=C2)C(N)=N)C(Br)=C1

InChI

InChIKey=VFDASNWZZRLEAU-UHFFFAOYSA-N
InChI=1S/C17H18Br2N4O2.2C2H6O4S/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19;2*3-1-2-7(4,5)6/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)

HIDE SMILES / InChI
Molecular Formula C2H6O4S
Molecular Weight 126.132
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C17H18Br2N4O2
Molecular Weight 470.158
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf

Dibrompropamidine isetionate is an antiseptic. Ointment containing dibrompropamidine isetionate is used to treat minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
BROLENE

Approved Use

Dibrompropamidine isetionate is used for minor infections of the eye or eyelid.
PubMed

PubMed

TitleDatePubMed
Studies on the mode of action of dibromopropamidine.
1973 Jun-Aug
In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.
2001
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear.
2007 Nov
Acanthamoeba keratitis: 2007: a train wreck in slow motion.
2007 Sep
[When the treatment is the problem].
2009 Feb 12
[Graze with unusual progress].
2009 Feb 12
Cosmetic contact lens-related Acanthamoeba keratitis.
2009 May

Sample Use Guides

In Vivo Use Guide
Eye ointment containing dibrompropamidine isethionate 0.15% w/w to the affected eye once or twice each day for at least 2 days
Route of Administration: Topical
In Vitro Use Guide
Dibrompropamidine isethionate, 300 μg/ml in aqueous solution was rapidly bactericidal, killing 99.9% of E. coli 15 TAU cells in 3 min.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:06:03 GMT 2023
Edited
by admin
on Fri Dec 15 15:06:03 GMT 2023
Record UNII
12Y597MO62
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIBROMPROPAMIDINE ISETHIONATE
Common Name English
4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMO-BENZENECARBOXIMIDAMIDE, BIS(2-HYDROXYETHANESULFONATE)
Common Name English
4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMO-BENZENECARBOXIMIDAMIDE, BIS(2-HYDROXYETHANESULPHONATE)
Common Name English
DIBROMPROPAMIDINE ISETIONATE
MART.   WHO-DD  
Common Name English
DIBROMOPROPAMIDINE DIISETHIONATE [INCI]
Common Name English
Dibrompropamidine isetionate [WHO-DD]
Common Name English
NSC-33424
Code English
DIBROMPROPAMIDINE DIISETIONATE
EP  
Common Name English
NSC-528031
Code English
DIBROMPROPAMIDINE DIISETIONATE [EP MONOGRAPH]
Common Name English
DIBROMOPROPAMIDINE ISETHIONATE [MI]
Common Name English
DIBROMPROPAMIDINE DI-ISETHIONATE
Common Name English
DIBROMOPROPAMIDINE ISETHIONATE
MI  
Common Name English
DIBROMOPROPAMIDINE DIISETHIONATE
INCI  
INCI  
Official Name English
DIBROMPROPAMIDINE ISETIONATE [MART.]
Common Name English
Code System Code Type Description
ECHA (EC/EINECS)
210-399-5
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
PUBCHEM
16735405
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
SMS_ID
100000092617
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
EVMPD
SUB01662MIG
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
RXCUI
22862
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY RxNorm
CAS
614-87-9
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
MERCK INDEX
m4299
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY Merck Index
FDA UNII
12Y597MO62
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
MESH
C053597
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID30210332
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
NSC
528031
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
NSC
33424
Created by admin on Fri Dec 15 15:06:04 GMT 2023 , Edited by admin on Fri Dec 15 15:06:04 GMT 2023
PRIMARY
Related Record Type Details
Structure of ISETHIONIC ACID
PARENT -> SALT/SOLVATE
Structure of DIBROMPROPAMIDINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DIBROMPROPAMIDINE
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