DIBROMPROPAMIDINE ISETHIONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H18Br2N4O2.2C2H6O4S
Molecular Weight	722.422
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIBROMPROPAMIDINE ISETHIONATE

Structure Search

SMILES

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)C1=CC=C(OCCCOC2=C(Br)C=C(C=C2)C(N)=N)C(Br)=C1

InChI

InChIKey=VFDASNWZZRLEAU-UHFFFAOYSA-N

InChI=1S/C17H18Br2N4O2.2C2H6O4S/c18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19;2*3-1-2-7(4,5)6/h2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)

HIDE SMILES / InChI

Molecular Formula	C2H6O4S
Molecular Weight	126.132
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C17H18Br2N4O2
Molecular Weight	470.158
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4358232
Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf

Dibrompropamidine isetionate is an antiseptic. Ointment containing dibrompropamidine isetionate is used to treat minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
http://purl.obolibrary.org/obo/OMIT_0002795 3 Target ID: http://purl.obolibrary.org/obo/OMIT_0002795 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7996383 \| https://www.ncbi.nlm.nih.gov/pubmed/8229701 \| https://www.ncbi.nlm.nih.gov/pubmed/4358232	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Eye infections 13 Sources: http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf http://www.chemist.net/class/download.class.php?fileName=../sysimages/Brolene_Ointment_ds2355_1.pdf	Curative		Approved 8429	BROLENE Approved Use Dibrompropamidine isetionate is used for minor infections of the eye or eyelid.

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Eye ointment containing dibrompropamidine isethionate 0.15% w/w to the affected eye once or twice each day for at least 2 days

Route of Administration: Topical

In Vitro Use Guide

Dibrompropamidine isethionate, 300 μg/ml in aqueous solution was rapidly bactericidal, killing 99.9% of E. coli 15 TAU cells in 3 min.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:06:03 UTC 2023` Edited by `admin` on `Fri Dec 15 15:06:03 UTC 2023`
Record UNII	12Y597MO62
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIBROMPROPAMIDINE ISETHIONATE

Common Name

English

4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMO-BENZENECARBOXIMIDAMIDE, BIS(2-HYDROXYETHANESULFONATE)

Common Name

English

4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMO-BENZENECARBOXIMIDAMIDE, BIS(2-HYDROXYETHANESULPHONATE)

Common Name

English

DIBROMPROPAMIDINE ISETIONATE

Common Name

English

DIBROMOPROPAMIDINE DIISETHIONATE [INCI]

Common Name

English

Dibrompropamidine isetionate [WHO-DD]

Common Name

English

NSC-33424

Code

English

DIBROMPROPAMIDINE DIISETIONATE

Common Name

English

NSC-528031

Code

English

DIBROMPROPAMIDINE DIISETIONATE [EP MONOGRAPH]

Common Name

English

DIBROMOPROPAMIDINE ISETHIONATE [MI]

Common Name

English

DIBROMPROPAMIDINE DI-ISETHIONATE

Common Name

English

DIBROMOPROPAMIDINE ISETHIONATE

Common Name

English

DIBROMOPROPAMIDINE DIISETHIONATE

Official Name

English

DIBROMPROPAMIDINE ISETIONATE [MART.]

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

210-399-5