Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C27H22F4N4O3S.ClH.H2O |
| Molecular Weight | 613.023 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Cl.FC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=O)C3=CC=C(NC4=CC=NC5=CC(=CC=C45)C(F)(F)F)C=C3
InChI
InChIKey=FLWHGDVIICGHDP-UHFFFAOYSA-N
InChI=1S/C27H22F4N4O3S.ClH.H2O/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;;/h1-12,17H,13-16H2,(H,32,33);1H;1H2
Losulazine (U-54,669F) is an antihypertensive agent acting by a sympatholytic mechanism. It appears to alter peripheral sympathetic neurogenic function but apparently does not enter the central nervous system. Losulazine effectively lowered the blood pressure in patients with hypertension.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Study on the activities of testes and accessory sex glands after losulazine treatment in rats. | 1994-09 |
|
| Comparison of the effects of losulazine and reserpine on central aminergic neurons. | 1993-11 |
|
| Mechanism of anestrus in rats treated with an antihypertensive agent, losulazine hydrochloride. | 1987-01 |
|
| 7-(Trifluoromethyl)-4-aminoquinoline hypotensives: novel peripheral sympatholytics. | 1986-01 |
|
| Losulazine, a new antihypertensive. | 1985-08 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
6917756
Created by
admin on Mon Mar 31 17:36:37 GMT 2025 , Edited by admin on Mon Mar 31 17:36:37 GMT 2025
|
PRIMARY | |||
|
267UX099PD
Created by
admin on Mon Mar 31 17:36:37 GMT 2025 , Edited by admin on Mon Mar 31 17:36:37 GMT 2025
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD
