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Description
Curator's Comment:: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm

Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.

Originator

Curator's Comment:: Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). http://www.sciencedirect.com/science/article/pii/S0140673600701000 reference retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18132350

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Primary
CETRIMIDE

Approved Use

Cetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
PubMed

PubMed

TitleDatePubMed
The effects of two quaternary ammonium compounds on citric acid and sterol synthesis in Aspergillus niger.
1963 Apr
Antiseptics and disinfectants: activity, action, and resistance.
1999 Jan
Patents

Sample Use Guides

Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area. Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.
Route of Administration: Topical
Cetrimide, at 30 ug/ml inhibited growth of Aspergillus niger.
Name Type Language
CETRIMIDE
EP   INN   MART.   WHO-DD   WHO-IP  
INN  
Official Name English
LISSOLAMINE V
Common Name English
CETRIMIDUM [WHO-IP LATIN]
Common Name English
CETRIMIDE BROMIDE
Common Name English
TRIMETHYLTETRADECYLAMMONIUM BROMIDE AND MAY CONTAIN SMALLER AMOUNTS OF DODECYLTRIMETHYLAMMONIUM BROMIDE AND HEXADECYLTRIMETHYLAMMONIUM BROMIDE
Common Name English
QUAMMONIUM
Common Name English
CETRIMIDE [EP MONOGRAPH]
Common Name English
CETRIMIDE [WHO-IP]
Common Name English
CETRIMIDE [WHO-DD]
Common Name English
CETRIMIDE [MART.]
Common Name English
CETRIMIDE [INN]
Common Name English
SUTICIDE
Common Name English
Classification Tree Code System Code
WHO-ATC D08AJ04
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
WHO-VATC QD08AJ04
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
WHO-VATC QD11AC01
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
WHO-ATC D11AC01
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
Code System Code Type Description
WHO INTERNATIONAL PHARMACOPEIA
CETRIMIDE
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY Description: A white or almost white, voluminous, free-flowing powder; odour, slight, characteristic. Solubility: Freely soluble in water and ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Antimicrobial preservative. Storage: Cetrimide should be stored in a well-closed container. Definition: Cetrimide is a mixture consisting mainly of tetradecyltrimethylammonium bromide together with smaller amounts of dodecyltrimethylammonium bromide and hexadecyltrimethylammonium bromide.Cetrimide contains not less than 96.0% and not more than the equivalent of 101.0% of alkyltrimethylammonium bromides, calculated as C17H38BrN (relative molecular mass = 336.4) and with reference to the dried substance.
CAS
8044-71-1
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
EVMPD
SUB01173MIG
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
ChEMBL
CHEMBL1180003
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
FDA UNII
24QSH2NL8N
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
NCI_THESAURUS
C166539
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
DRUG CENTRAL
4360
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
EVMPD
SUB42953
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
INN
5157
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY
RXCUI
288088
Created by admin on Fri Jun 25 21:16:18 UTC 2021 , Edited by admin on Fri Jun 25 21:16:18 UTC 2021
PRIMARY RxNorm
Definition References