DescriptionCurator's Comment: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm
Curator's Comment: Description was created based on several sources, including http://www.americanpharmaceuticalreview.com/Featured-Articles/38886-Antimicrobial-Preservatives-Part-One-Choosing-a-Preservative-System/ | https://books.google.ru/books?id=EMrSBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/9880479 | http://www.medindia.net/doctors/drug_information/cetrimide.htm
Cetrimide is a quaternary ammonium compound. Cetrimide was first introduced as a combined cleanser and skin antiseptic by Barnes (1942). Cetrimide combines excellent detergent properties and minimal toxicity with a useful antiseptic action. Cetrimide affects membrane permeability allowing ‘leaking’ of essential cell constituents leading to cell death. This medication is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0002194 |
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Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | CETRIMIDE Approved UseCetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants. |
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| Primary | CETRIMIDE Approved UseCetrimide is a skin antiseptic and disinfectant prescribed for seborrhoeic dermatitis and wound cleansing. The cream has a bactericidal activity against gram-positive bacteria and incompatible with soaps and other anionic surfactants. |
Sample Use Guides
Wound cleansing - Topical : Adult: Apply 0.1-1% aqueous solution or 0.5% cream onto affected area.
Seborrhoeic dermatitis - Topical : Adult: Apply 10% shampoo solution onto the scalp.
Route of Administration:
Topical
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WHO-ATC |
D08AJ04
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WHO-VATC |
QD08AJ04
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WHO-VATC |
QD11AC01
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WHO-ATC |
D11AC01
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24QSH2NL8N
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CETRIMIDE
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PRIMARY | Description: A white or almost white, voluminous, free-flowing powder; odour, slight, characteristic. Solubility: Freely soluble in water and ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Antimicrobial preservative. Storage: Cetrimide should be stored in a well-closed container. Definition: Cetrimide is a mixture consisting mainly of tetradecyltrimethylammonium bromide together with smaller amounts of dodecyltrimethylammonium bromide and hexadecyltrimethylammonium bromide.Cetrimide contains not less than 96.0% and not more than the equivalent of 101.0% of alkyltrimethylammonium bromides, calculated as C17H38BrN (relative molecular mass = 336.4) and with reference to the dried substance. | ||
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8044-71-1
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CHEMBL1180003
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DTXSID901018728
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C166539
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4360
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SUB42953
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2284
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5157
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288088
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3567
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All of the following components must be present:
ACTIVE MOIETY
SUBSTANCE RECORD
