Details
Stereochemistry | ACHIRAL |
Molecular Formula | C4H4NO4S.K |
Molecular Weight | 201.242 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].CC1=CC([O-])=NS(=O)(=O)O1
InChI
InChIKey=WBZFUFAFFUEMEI-UHFFFAOYSA-M
InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1
Acesulfame is a non-nutritive sweetener Acesulfame potassium is a calorie-free artificial sweetener, also known as Acesulfame K or Ace K (K being the symbol for potassium), and marketed under the trade names Sunett and Sweet One. In the European Union, it is known under the E number (additive code) E950. It was discovered accidentally in 1967 by German chemist Karl Clauss at Hoechst AG (now Nutrinova). In chemical structure, acesulfame potassium is the potassium salt of 6-methyl-1,2,3- oxathiazine-4(3H)-one 2,2-dioxide. Acesulfame K has been approved for a variety of uses in more than 90 countries. In 1998, the FDA broadened the US approval of acesulfame K to allow its use in nonalcoholic beverages. It is often blended with sucralose and used to decrease the bitter aftertaste of aspartame. A wide range of low-calorie foods and drinks contain acesulfame K, including table-top sweeteners, chewing gum, jam, dairy products, frozen desserts, drinks and baked goods. Acesulfame K is not broken down when digested, nor is it stored in the body. After being consumed, it is quickly absorbed by the body and then rapidly excreted, unchanged.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL3594 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25019479 |
2.41 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Acesulfame K Approved UseNonnutritive sweetener Launch Date1988 |
PubMed
Title | Date | PubMed |
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Calculation of the intake of three intense sweeteners in young insulin-dependent diabetics. | 2001 Jul |
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[Simultaneous determination of various food additives by high performance liquid chromatography]. | 2001 Mar |
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Fluoride concentration and pH of iced tea products. | 2002 Nov-Dec |
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Sweet success: Ionic liquids derived from non-nutritive sweeteners. | 2004 Mar 21 |
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Bis(acesulfamato-kappa2N3,O4)bis(2-aminopyrimidine-kappaN1)copper(II). | 2005 May |
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Taste masking analysis in pharmaceutical formulation development using an electronic tongue. | 2006 Mar 9 |
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Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis. | 2006 May |
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The erosive potential of some flavoured waters. | 2007 Jan |
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Glucose sensing in L cells: a primary cell study. | 2008 Dec |
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Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss. | 2008 Oct 26 |
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Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days. | 2009 |
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General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats. | 2009 Aug |
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[Simultaneous determination of artificial sweeteners in beverage by ultra performance liquid chromatography]. | 2009 Jan |
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Standards of medical care in diabetes--2009. | 2009 Jan |
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Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). | 2009 Jul |
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Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial. | 2009 Jul 22 |
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Ubiquitous occurrence of the artificial sweetener acesulfame in the aquatic environment: an ideal chemical marker of domestic wastewater in groundwater. | 2009 Jun 15 |
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Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo. | 2009 Mar |
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In vivo cytogenetic studies on aspartame. | 2010 |
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[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry]. | 2010 Aug |
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[Simultaneous determination of six food additives in meat products by high performance liquid chromatography]. | 2010 Dec |
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Impact of ionic liquids in environment and humans: an overview. | 2010 Dec |
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Standards of medical care in diabetes--2010. | 2010 Jan |
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Inadequate toxicity tests of food additive acesulfame. | 2010 Jan-Mar |
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Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings: Neuroscience 2010. | 2010 Jun |
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Performance of conventional multi-barrier drinking water treatment plants for the removal of four artificial sweeteners. | 2010 Jun |
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An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine. | 2010 Jun |
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Modulation of bitter taste perception by a small molecule hTAS2R antagonist. | 2010 Jun 22 |
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[Simultaneous determination of various aseptics and sweeteners in milk and dairy products]. | 2010 Mar |
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Pt(II) and Ag(I) complexes with acesulfame: crystal structure and a study of their antitumoral, antimicrobial and antiviral activities. | 2010 May |
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Polymorphism in acesulfame sweetener: structure-property and stability relationships of bending and brittle crystals. | 2010 May 28 |
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Rational development of taste masked oral liquids guided by an electronic tongue. | 2010 Nov 15 |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17046038
Acesulfame`s effect on the contractile response of isolated rat detrusor muscle strips was evaluated. The atropine-resistant response to EFS was marginally increased by acesulfame K 10(-6) M. Acesulfame K 10(-6) M increased the maximum contractile response to alpha,beta methylene ATP by 35% (+/-9.6%) (p<0.05) and to KCl by 12% (+/-3.1%) (p<0.01). Acesulfame K 10(-6) M increased the log EC(50) from -2.79 (+/-0.037) to -3.03 (+/-0.048, p<0.01).
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C283
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CFR |
21 CFR 172.800
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JECFA EVALUATION |
INS-950
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CODEX ALIMENTARIUS (GSFA) |
INS-950
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DSLD |
1179 (Number of products:14)
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11074431
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DTXSID1030606
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m1308
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CHEMBL176687
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1002505
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760104
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23OV73Q5G9
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55589-62-3
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100000076648
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23OV73Q5G9
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C76512
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259-715-3
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ACESULFAME POTASSIUM
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C006362
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1310545
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SUB11688MIG
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ACTIVE MOIETY
SUBSTANCE RECORD