U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C26H31N3O2.ClH
Molecular Weight 454.004
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BP-897

SMILES

Cl.COC1=CC=CC=C1N2CCN(CCCCNC(=O)C3=CC=C4C=CC=CC4=C3)CC2

InChI

InChIKey=KFWJGUZIZAPFMX-UHFFFAOYSA-N
InChI=1S/C26H31N3O2.ClH/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23;/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30);1H

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.92 nM [Ki]
61.0 nM [Ki]
3.0 µM [Ki]
0.3 µM [Ki]
PubMed

PubMed

TitleDatePubMed
Role of dopamine D3 receptors in thermoregulation: a reappraisal.
2000 Jan 17
The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors.
2001 Jul 20
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.
2003 Jun
Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys.
2004 Nov
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.
2006 Dec 1
Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats.
2006 Jan 4
Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats.
2006 Nov
Differential involvement of dopamine receptors in conditioned suppression induced by cocaine.
2007 Nov 14
Name Type Language
BP-897
Common Name English
2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-, MONOHYDROCHLORIDE
Systematic Name English
Code System Code Type Description
WIKIPEDIA
BP-897
Created by admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
PRIMARY
CAS
314776-92-6
Created by admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
PRIMARY
PUBCHEM
3038494
Created by admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
PRIMARY
EPA CompTox
DTXSID60953482
Created by admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
PRIMARY
FDA UNII
20PLE5W821
Created by admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
PRIMARY