Details
Stereochemistry | ACHIRAL |
Molecular Formula | C26H31N3O2.ClH |
Molecular Weight | 454.004 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.COC1=CC=CC=C1N2CCN(CCCCNC(=O)C3=CC=C4C=CC=CC4=C3)CC2
InChI
InChIKey=KFWJGUZIZAPFMX-UHFFFAOYSA-N
InChI=1S/C26H31N3O2.ClH/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23;/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30);1H
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116 |
0.92 nM [Ki] | ||
Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116 |
61.0 nM [Ki] | ||
Target ID: CHEMBL2056 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116 |
3.0 µM [Ki] | ||
Target ID: CHEMBL219 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116 |
0.3 µM [Ki] |
PubMed
Title | Date | PubMed |
---|---|---|
Role of dopamine D3 receptors in thermoregulation: a reappraisal. | 2000 Jan 17 |
|
The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors. | 2001 Jul 20 |
|
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. | 2003 Jun |
|
Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys. | 2004 Nov |
|
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo. | 2006 Dec 1 |
|
Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats. | 2006 Jan 4 |
|
Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats. | 2006 Nov |
|
Differential involvement of dopamine receptors in conditioned suppression induced by cocaine. | 2007 Nov 14 |
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
BP-897
Created by
admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
|
PRIMARY | |||
|
314776-92-6
Created by
admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
|
PRIMARY | |||
|
3038494
Created by
admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
|
PRIMARY | |||
|
DTXSID60953482
Created by
admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
|
PRIMARY | |||
|
20PLE5W821
Created by
admin on Sat Dec 16 08:35:31 GMT 2023 , Edited by admin on Sat Dec 16 08:35:31 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD