Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C26H31N3O2 |
| Molecular Weight | 417.5432 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=CC=C1N2CCN(CCCCNC(=O)C3=CC=C4C=CC=CC4=C3)CC2
InChI
InChIKey=MNHDKMDLOJSCGN-UHFFFAOYSA-N
InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30)
| Molecular Formula | C26H31N3O2 |
| Molecular Weight | 417.5432 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Differential involvement of dopamine receptors in conditioned suppression induced by cocaine. | 2007-11-14 |
|
| Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo. | 2006-12-01 |
|
| Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats. | 2006-11 |
|
| Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats. | 2006-01-04 |
|
| Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors. | 2005-07 |
|
| Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats. | 2005-05 |
|
| Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys. | 2004-11 |
|
| Agents in development for the management of cocaine abuse. | 2004 |
|
| N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands. | 2003-08-28 |
|
| Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. | 2003-06 |
|
| BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction. | 2003 |
|
| The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors. | 2001-07-20 |
|
| BP-897 Bioprojet. | 2000-09 |
|
| Role of dopamine D3 receptors in thermoregulation: a reappraisal. | 2000-01-17 |
|
| Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist. | 1999-07-22 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:11:34 GMT 2025
by
admin
on
Mon Mar 31 22:11:34 GMT 2025
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| Record UNII |
2FVL90IM8I
|
| Record Status |
Validated (UNII)
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| Record Version |
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2FVL90IM8I
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192384-87-5
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3038495
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