DO-687

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H31N3O2
Molecular Weight	417.5432
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=CC=C1N2CCN(CCCCNC(=O)C3=CC=C4C=CC=CC4=C3)CC2

InChI

InChIKey=MNHDKMDLOJSCGN-UHFFFAOYSA-N

InChI=1S/C26H31N3O2/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30)

HIDE SMILES / InChI

Molecular Formula	C26H31N3O2
Molecular Weight	417.5432
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Dopamine D3 receptor 91 Target ID: CHEMBL234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Partial Agonist 290	0.92 nM [Ki]
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	61.0 nM [Ki]
Dopamine D1 receptor 101 Target ID: CHEMBL2056 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	3.0 µM [Ki]
Dopamine D4 receptor 71 Target ID: CHEMBL219 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	0.3 µM [Ki]

PubMed

Title	Date	PubMed
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist.	1999 Jul 22	10432116
Role of dopamine D3 receptors in thermoregulation: a reappraisal.	2000 Jan 17	10683862
The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors.	2001 Jul 20	11476753
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.	2003 Jun	12740572
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.	2006 Dec 1	16952157
Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats.	2006 Nov	16814282
Differential involvement of dopamine receptors in conditioned suppression induced by cocaine.	2007 Nov 14	17628537

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:35:31 GMT 2023` Edited by `admin` on `Sat Dec 16 08:35:31 GMT 2023`
Record UNII	2FVL90IM8I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DO-687

Common Name

English

2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-

Systematic Name

English

BP-897 FREE BASE

Code

English

Code System Code Type Description

FDA UNII

2FVL90IM8I

Created by admin on Sat Dec 16 08:35:32 GMT 2023 , Edited by admin on Sat Dec 16 08:35:32 GMT 2023

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CAS

192384-87-5

Created by admin on Sat Dec 16 08:35:32 GMT 2023 , Edited by admin on Sat Dec 16 08:35:32 GMT 2023

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PUBCHEM

3038495

Created by admin on Sat Dec 16 08:35:32 GMT 2023 , Edited by admin on Sat Dec 16 08:35:32 GMT 2023

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Related Record Type Details


					2FVL90IM8I

DO-687

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