BP-897

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H31N3O2.ClH
Molecular Weight	454.004
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC=CC=C1N2CCN(CCCCNC(=O)C3=CC=C4C=CC=CC4=C3)CC2

InChI

InChIKey=KFWJGUZIZAPFMX-UHFFFAOYSA-N

InChI=1S/C26H31N3O2.ClH/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23;/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30);1H

HIDE SMILES / InChI

Molecular Formula	C26H31N3O2
Molecular Weight	417.5432
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Dopamine D3 receptor 91 Target ID: CHEMBL234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Partial Agonist 290	0.92 nM [Ki]
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	61.0 nM [Ki]
Dopamine D1 receptor 101 Target ID: CHEMBL2056 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	3.0 µM [Ki]
Dopamine D4 receptor 71 Target ID: CHEMBL219 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	0.3 µM [Ki]

PubMed

Title	Date	PubMed
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist.	1999 Jul 22	10432116
Role of dopamine D3 receptors in thermoregulation: a reappraisal.	2000 Jan 17	10683862
BP-897 Bioprojet.	2000 Sep	11249586
The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors.	2001 Jul 20	11476753
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.	2003 Aug 28	12930150
Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function.	2003 Jun	12740572
BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction.	2003 Summer	12847556
Agents in development for the management of cocaine abuse.	2004	15233592
Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys.	2004 Nov	15226382
Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors.	2005 Jul	15858839
Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats.	2005 May	15619116
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.	2006 Dec 1	16952157
Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats.	2006 Jan 4	16005579
Actions at sites other than D(3) receptors mediate the effects of BP897 on l-DOPA-induced hyperactivity in monoamine-depleted rats.	2006 Nov	16814282
Differential involvement of dopamine receptors in conditioned suppression induced by cocaine.	2007 Nov 14	17628537

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:35:31 UTC 2023` Edited by `admin` on `Sat Dec 16 08:35:31 UTC 2023`
Record UNII	20PLE5W821
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BP-897

Common Name

English

2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-, MONOHYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

BP-897