BP-897

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H31N3O2.ClH
Molecular Weight	454.004
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC=CC=C1N2CCN(CCCCNC(=O)C3=CC=C4C=CC=CC4=C3)CC2

InChI

InChIKey=KFWJGUZIZAPFMX-UHFFFAOYSA-N

InChI=1S/C26H31N3O2.ClH/c1-31-25-11-5-4-10-24(25)29-18-16-28(17-19-29)15-7-6-14-27-26(30)23-13-12-21-8-2-3-9-22(21)20-23;/h2-5,8-13,20H,6-7,14-19H2,1H3,(H,27,30);1H

HIDE SMILES / InChI

Molecular Formula	C26H31N3O2
Molecular Weight	417.5432
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
Dopamine D3 receptor 91 Target ID: CHEMBL234 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Partial Agonist 290	0.92 nM [Ki]
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	61.0 nM [Ki]
Dopamine D1 receptor 101 Target ID: CHEMBL2056 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	3.0 µM [Ki]
Dopamine D4 receptor 71 Target ID: CHEMBL219 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10432116	Binding Agent 1064	0.3 µM [Ki]

PubMed

Title	Date	PubMed
N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.	2003 Aug 28	12930150
BP 897, a selective dopamine D3 receptor ligand with therapeutic potential for the treatment of cocaine-addiction.	2003 Summer	12847556
Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeys.	2004 Nov	15226382
Acute administration of SB-277011A, NGB 2904, or BP 897 inhibits cocaine cue-induced reinstatement of drug-seeking behavior in rats: role of dopamine D3 receptors.	2005 Jul	15858839
Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo.	2006 Dec 1	16952157
Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats.	2006 Jan 4	16005579
Differential involvement of dopamine receptors in conditioned suppression induced by cocaine.	2007 Nov 14	17628537

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:35:31 GMT 2023` Edited by `admin` on `Sat Dec 16 08:35:31 GMT 2023`
Record UNII	20PLE5W821
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BP-897

Common Name

English

2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

2-NAPHTHALENECARBOXAMIDE, N-(4-(4-(2-METHOXYPHENYL)-1-PIPERAZINYL)BUTYL)-, MONOHYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

BP-897