U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C17H20BrNO.ClH
Molecular Weight 370.712
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROMODIPHENHYDRAMINE HYDROCHLORIDE

SMILES

Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(Br)C=C2

InChI

InChIKey=ZQDJSWUEGOYDGT-UHFFFAOYSA-N
InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H

HIDE SMILES / InChI
Bromodiphenhydramine also known as bromazine, is an antihistamine and anticholinergic agent, which was used to under brand name ambordyl. Ambordyfor was indicated for the treatment of allergic symptoms, but that usage, was discontinued. It was shown, that bromodiphenhydramine competed with free histamine for binding at HA-receptor sites and lead to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
AMBODRYL

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms.
1955 May-Jun
Patents

Patents

Sample Use Guides

Unknown
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: The antihistamine compound promethazine (Pz) showed significant antibacterial action when tested against 124 strains of aerobic and 13 strains of anaerobic bacteria belonging to both Gram positive and Gram negative genera. Six Pz-sensitive strains were found to be simultaneously sensitive to similar non-conventional antimicrobics, e.g., methdilazine, bromodiphenhydramine. A high degree of synergism was observed in vitro when Pz was used in combination with methdilazine and bromodiphenhydramine.
Unknown
Name Type Language
BROMODIPHENHYDRAMINE HYDROCHLORIDE
MI   ORANGE BOOK   USP   USP-RS   VANDF  
Common Name English
2-((P-BROMO-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE HYDROCHLORIDE
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [MI]
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [VANDF]
Common Name English
BROMODIPHENHYDRAMINE HCL
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
BROMANYL COMPONENT BROMODIPHENHYDRAMINE HYDROCHLORIDE
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [USP-RS]
Common Name English
AMBENYL COMPONENT BROMODIPHENHYDRAMINE HYDROCHLORIDE
Common Name English
AMBODRYL
Brand Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE COMPONENT OF AMBENYL
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE COMPONENT OF BROMANYL
Common Name English
Bromazine hydrochloride [WHO-DD]
Common Name English
ETHANAMINE, 2-((4-BROMOPHENYL)PHENYLMETHOXY)-N,N-DIMETHYL-, HYDROCHORIDE
Common Name English
NSC-36113
Code English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
BROMAZINE HYDROCHLORIDE [MART.]
Common Name English
BROMAZINE HYDROCHLORIDE
MART.   WHO-DD  
Systematic Name English
2-(4-BROMOBENZHYDRYLOXY)-N,N-DIMETHYLETHYLAMINE HYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
Code System Code Type Description
EVMPD
SUB00871MIG
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
NCI_THESAURUS
C47421
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
DRUG BANK
DBSALT000791
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
CAS
1808-12-4
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
DAILYMED
202J683U97
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
PUBCHEM
15736
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201245
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID70904541
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
NSC
36113
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
FDA UNII
202J683U97
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
MERCK INDEX
m2698
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
217-310-9
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
CHEBI
59178
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
SMS_ID
100000085142
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
MESH
C011410
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
RS_ITEM_NUM
1077005
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY
RXCUI
91065
Created by admin on Fri Dec 15 15:36:47 GMT 2023 , Edited by admin on Fri Dec 15 15:36:47 GMT 2023
PRIMARY RxNorm