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Details

Stereochemistry RACEMIC
Molecular Formula C17H20BrNO.ClH
Molecular Weight 370.712
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BROMODIPHENHYDRAMINE HYDROCHLORIDE

SMILES

Cl.CN(C)CCOC(C1=CC=CC=C1)C2=CC=C(Br)C=C2

InChI

InChIKey=ZQDJSWUEGOYDGT-UHFFFAOYSA-N
InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula C17H20BrNO
Molecular Weight 334.251
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Bromodiphenhydramine also known as bromazine, is an antihistamine and anticholinergic agent, which was used to under brand name ambordyl. Ambordyfor was indicated for the treatment of allergic symptoms, but that usage, was discontinued. It was shown, that bromodiphenhydramine competed with free histamine for binding at HA-receptor sites and lead to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

Approval Year

1951
104
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
AMBODRYL

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY34571
https://www.001chemical.com/chem/118-23-0
001 Chemical
DY34576
https://www.001chemical.com/chem/118081-34-8
ABI Chem
AC1L1DOW
Ambinter
Amb22500288
http://www.ambinter.com/reference/22500288
Angel Pharmatech
AG-10534
http://www.angelpharmatech.com/118-23-0.html
BLD Pharm
BD142761
http://www.bldpharm.com/products/118-23-0.html
BOC Sciences
118-23-0
BOC Sciences
1808-12-4
ChemTik
CTK8G6492
Chemieliva Pharmaceutical Co., Ltd
PBCM0120578
Compound Cloud
15736
Compound Cloud
2444
Hangzhou Yuhao Chemical Technology
RT3395
HongKong Chemhere
SCA38732
Molcore
MC34571
https://www.molcore.com/product/118-23-0
Molcore
MC34576
https://www.molcore.com/product/118081-34-8
MuseChem
M068119
NovoSeek
2444
PI Chemicals
PI-35967
Sigma Aldrich
1077005
Sigma Aldrich
1077005|USP
Sigma Aldrich
62881
Sigma Aldrich
62881|SIAL
Sigma Aldrich
PHR1861
Smolecule
S569621
https://www.smolecule.com/products/s569621
THE BioTek
bt-363827
https://www.thebiotek.com/product/others/bt-363827
Toronto Research Chemicals
B678525
ZINC
ZINC000000000095
http://zinc15.docking.org/substances/ZINC000000000095
ZINC
ZINC000001668588
http://zinc15.docking.org/substances/ZINC000001668588
eMolecules
42851214
eMolecules
49258329
eNovation Chemicals
K50523
https://www.enovationchem.com/ProductDetails.asp?ProductID=K50523
eNovation Chemicals
Y1012711
https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1012711
PubMed

PubMed

TitleDatePubMed
A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms.
1955 May-Jun
Patents

Patents

US5968554
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: The antihistamine compound promethazine (Pz) showed significant antibacterial action when tested against 124 strains of aerobic and 13 strains of anaerobic bacteria belonging to both Gram positive and Gram negative genera. Six Pz-sensitive strains were found to be simultaneously sensitive to similar non-conventional antimicrobics, e.g., methdilazine, bromodiphenhydramine. A high degree of synergism was observed in vitro when Pz was used in combination with methdilazine and bromodiphenhydramine.
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:36:47 UTC 2023
Edited
by admin
on Fri Dec 15 15:36:47 UTC 2023
Record UNII
202J683U97
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BROMODIPHENHYDRAMINE HYDROCHLORIDE
MI   ORANGE BOOK   USP   USP-RS   VANDF  
Common Name English
2-((P-BROMO-.ALPHA.-PHENYLBENZYL)OXY)-N,N-DIMETHYLETHYLAMINE HYDROCHLORIDE
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [MI]
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [VANDF]
Common Name English
BROMODIPHENHYDRAMINE HCL
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [ORANGE BOOK]
Common Name English
BROMANYL COMPONENT BROMODIPHENHYDRAMINE HYDROCHLORIDE
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [USP-RS]
Common Name English
AMBENYL COMPONENT BROMODIPHENHYDRAMINE HYDROCHLORIDE
Common Name English
AMBODRYL
Brand Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE COMPONENT OF AMBENYL
Common Name English
BROMODIPHENHYDRAMINE HYDROCHLORIDE COMPONENT OF BROMANYL
Common Name English
Bromazine hydrochloride [WHO-DD]
Common Name English
ETHANAMINE, 2-((4-BROMOPHENYL)PHENYLMETHOXY)-N,N-DIMETHYL-, HYDROCHORIDE
Common Name English
NSC-36113
Code English
BROMODIPHENHYDRAMINE HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
BROMAZINE HYDROCHLORIDE [MART.]
Common Name English
BROMAZINE HYDROCHLORIDE
MART.   WHO-DD  
Systematic Name English
2-(4-BROMOBENZHYDRYLOXY)-N,N-DIMETHYLETHYLAMINE HYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29578
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
Code System Code Type Description
EVMPD
SUB00871MIG
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
NCI_THESAURUS
C47421
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
DRUG BANK
DBSALT000791
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
CAS
1808-12-4
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
DAILYMED
202J683U97
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
PUBCHEM
15736
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201245
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
EPA CompTox
DTXSID70904541
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
NSC
36113
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
FDA UNII
202J683U97
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
MERCK INDEX
m2698
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
217-310-9
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
CHEBI
59178
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
SMS_ID
100000085142
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
MESH
C011410
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
RS_ITEM_NUM
1077005
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY
RXCUI
91065
Created by admin on Fri Dec 15 15:36:47 UTC 2023 , Edited by admin on Fri Dec 15 15:36:47 UTC 2023
PRIMARY RxNorm
Related Record Type Details
Structure of BROMODIPHENHYDRAMINE
ACTIVE MOIETY
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