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Details

Stereochemistry ACHIRAL
Molecular Formula C8H18NO2.Cl
Molecular Weight 195.687
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARPRONIUM CHLORIDE

SMILES

[Cl-].COC(=O)CCC[N+](C)(C)C

InChI

InChIKey=RZMKWKZIJJNSLQ-UHFFFAOYSA-M
InChI=1S/C8H18NO2.ClH/c1-9(2,3)7-5-6-8(10)11-4;/h5-7H2,1-4H3;1H/q+1;/p-1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/22171995 and http://www.rad-ar.or.jp/siori/english/kekka.cgi?n=1602

Carpronium chloride is a hair growth reagent with a vasodilatory action. In vivo studies indicated that carpronium chloride achieved dilatation of vascular smooth muscle in the microcirculation of rats. FUROZIN SOLUTION 5% (active ingredient Carpronium chloride) has local vasodilating effect and hair growth stimulatory effect to improve alopecia and vitiligo. It is usually used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
FUROZIN SOLUTION 5%

Approved Use

Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Primary
FUROZIN SOLUTION 5%

Approved Use

Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
Primary
FUROZIN SOLUTION 5%

Approved Use

Used for the prevention of hair loss, for hair growth stimulation, and in the treatment of seborrhea sicca and vitiligo vulgaris.
PubMed

PubMed

TitleDatePubMed
Seventeen cases of alopecia areata: combination of SADBE topical immunotherapy with other therapies.
2002 Oct
Study of active substances involved in skin dysfunction induced by crowding stress. I. Effect of crowding and isolation on some physiological variables, skin function and skin blood perfusion in hairless mice.
2003 Feb
Effects of carpronium chloride on the microvascular blood flow in rat mesentery using intravital videomicroscopy.
2006
Topical immunotherapy in alopecia areata.
2010 Jan
Patents

Sample Use Guides

For alopecia and seborrhea sicca: In general, apply appropriate amount of the medicine to the affected area; or sprinkle the medicine on the whole scalp; twice to 3 times daily, and gently massage the head. For vitiligo vulgaris: In general, apply appropriate amount of the medicine to the affected area, 3 to 4 times daily.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
CARPRONIUM CHLORIDE
INCI   INN   JAN   MI   WHO-DD  
INN   INCI  
Official Name English
FUROZIN
Brand Name English
CARPRONIUM CHLORIDE [MI]
Common Name English
CARPRONIUM CHLORIDE [INCI]
Common Name English
Carpronium chloride [WHO-DD]
Common Name English
ACTINAMIN
Brand Name English
carpronium chloride [INN]
Common Name English
(3-CARBOXYPROPYL)TRIMETHYLAMMONIUM CHLORIDE, METHYL ESTER
Common Name English
CARPRONIUM CHLORIDE [JAN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C47796
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL1896433
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
CHEBI
31362
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
NCI_THESAURUS
C77850
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
MERCK INDEX
m103
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
236-243-6
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
SMS_ID
100000081347
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
INN
2839
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
PUBCHEM
25804
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
WIKIPEDIA
CARPRONIUM CHLORIDE
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
CAS
13254-33-6
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
FDA UNII
1R01BKB74A
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID1046924
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY
EVMPD
SUB06145MIG
Created by admin on Fri Dec 15 16:14:39 GMT 2023 , Edited by admin on Fri Dec 15 16:14:39 GMT 2023
PRIMARY