Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H23NO4 |
| Molecular Weight | 341.4009 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12CC3=C(C(OC)=C(OC)C=C3)C4=C1C(CCN2C)=CC(OC)=C4O
InChI
InChIKey=IDQUPXZJURZAGF-ZDUSSCGKSA-N
InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1
Corydine is a naturally occurring compound which can be extracted from plants such as Chelidonium majus, Corydalis marschalliana, C. bulbosa, C slivenensis, Glaucium grandiflorum. Corydine has shown some efficacy as an anti-cancer compound in several cell models and was examined along with related compounds from Stephania dinklagei for antiprotozoal activities. (+)- and (-)- Corydine were tested as neuromuscular blocking agents were it was found that there was a modest preference for (+)-corydine.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P24941 Gene ID: 1017.0 Gene Symbol: CDK2 Target Organism: Homo sapiens (Human) |
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Target ID: P08684 Gene ID: 1576.0 Gene Symbol: CYP3A4 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether. | 1976 Nov 3 |
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| Alkaloids of Corydalis slivenensis. | 1982 Mar |
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| Corydine and norcorydine from the roots of Chelidonium majus. | 1998 Jun |
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| Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei. | 2003 Sep |
Patents
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1O1D15OP5R
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2593178
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1O1D15OP5R
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476-69-7
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m3803
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10153
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SUBSTANCE RECORD
