CORYDINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H23NO4
Molecular Weight	341.4009
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=C3[C@H](CC4=C(C(OC)=C(OC)C=C4)C3=C1O)N(C)CC2

InChI

InChIKey=IDQUPXZJURZAGF-ZDUSSCGKSA-N

InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)19(22)18-16(12)13(21)9-11-5-6-14(23-2)20(25-4)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H23NO4
Molecular Weight	341.4009
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17253273 | https://www.ncbi.nlm.nih.gov/pubmed/2290126 | https://www.ncbi.nlm.nih.gov/pubmed/124343 | https://www.ncbi.nlm.nih.gov/pubmed/17401850 | https://www.ncbi.nlm.nih.gov/pubmed/10909274

Corydine is a naturally occurring compound which can be extracted from plants such as Chelidonium majus, Corydalis marschalliana, C. bulbosa, C slivenensis, Glaucium grandiflorum. Corydine has shown some efficacy as an anti-cancer compound in several cell models and was examined along with related compounds from Stephania dinklagei for antiprotozoal activities. (+)- and (-)- Corydine were tested as neuromuscular blocking agents were it was found that there was a modest preference for (+)-corydine.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclin-dependent kinase 2 23 Target ID: P24941 Gene ID: 1017.0 Gene Symbol: CDK2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20097066	Inhibitor 8504
Cytochrome P450 3A4 127 Target ID: P08684 Gene ID: 1576.0 Gene Symbol: CYP3A4 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20851588	Inhibitor 8504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cancer 609 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2290126	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis.	2017-08-22	28831066
Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei.	2003-09	14598219
Corydine and norcorydine from the roots of Chelidonium majus.	1998-06	17253273
Alkaloids of Turkish Glaucium species.	1982-11	17396968
Alkaloids of Corydalis slivenensis.	1982-03	17402105
Alkaloids from Corydalis bulbosa.	1981-09	17402008
Alkaloids from Corydalis marschalliana.	1981-03	17401850
Selective ther cleavage in the aporphine series. Conversion of (S)-bulbocapnine into (S)-corytuberine and (S)-corydine methyl ether.	1976-11-03	14090

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:53:12 GMT 2025` Edited by `admin` on `Mon Mar 31 21:53:12 GMT 2025`
Record UNII	1O1D15OP5R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CORYDINE

Common Name

English

(+)-CORYDINE

Preferred Name

English

D-CORYDINE

Common Name

English

(6AS)-5,6,6A,7-TETRAHYDRO-2,10,11-TRIMETHOXY-6-METHYL-4H-DIBENZO(DE,G)QUINOLIN-1-OL

Systematic Name

English

(S)-(+)-CORYDINE

Common Name

English

GLAUCENTRINE

Common Name

English

CORYDINE [MI]

Common Name

English

CORYTUBERINE METHYL ETHER [MI]

Common Name

English

GLAUCENTRIN

Common Name

English

O11-METHYLCORYTUBERINE

Common Name

English

4H-DIBENZO(DE,G)QUINOLIN-1-OL, 5,6,6A,7-TETRAHYDRO-2,10,11-TRIMETHOXY-6-METHYL-, (6AS)-

Systematic Name

English

Code System Code Type Description

DAILYMED

1O1D15OP5R