U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2K.O4S
Molecular Weight 174.259
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Potassium sulfate

SMILES

[K+].[K+].[O-]S([O-])(=O)=O

InChI

InChIKey=OTYBMLCTZGSZBG-UHFFFAOYSA-L
InChI=1S/2K.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2

HIDE SMILES / InChI

Description

SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
SUPREP Bowel Prep Kit

Approved Use

SUPREP Bowel Prep Kit is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults.

Launch Date

2010
PubMed

PubMed

TitleDatePubMed
Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme.
1992 Apr
Heparan sulphate in the binding and activation of basic fibroblast growth factor.
1992 Dec
The role of stromal cell heparan sulphate in regulating haemopoiesis.
1996 May
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.
1996 Sep
Dopamine sulphate: an enigma resolved.
1999 Apr
The use of magnesium sulphate in the intensive care management of an Asian patient with tetanus.
1999 Jul
Heparan sulphate. Regulation of growth factors in the mammary gland.
2000
Magnesium sulphate versus phenytoin for eclampsia.
2000
Regulation of sulfate transport and synthesis of sulfur-containing amino acids.
2000 Jun
Herpes simplex virus: discovering the link between heparan sulphate and hereditary bone tumours.
2000 Nov-Dec
Magnesium sulphate versus lytic cocktail for eclampsia.
2001
Magnesium sulphate for preventing preterm birth in threatened preterm labour.
2002
Dermatan sulphate as an antithrombotic drug.
2002 Sep-Dec
Magnesium sulphate versus phenytoin for eclampsia.
2003
Magnesium sulphate versus diazepam for eclampsia.
2003
Glucosaminyl N-deacetylase/N-sulphotransferases in heparan sulphate biosynthesis and biology.
2003 Apr
Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition.
2003 Apr
Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies.
2003 Oct
Characterization of the Herpesvirus saimiri Orf51 protein.
2004 Aug 15
The SLC13 gene family of sodium sulphate/carboxylate cotransporters.
2004 Feb
Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?
2004 Jan
[The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair].
2004 May 1-15
Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery.
2005
Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily.
2006 Jun
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.
2006 Jun
Insights into the role of heparan sulphate in fibroblast growth factor signalling.
2006 Jun
The role of heparan sulphate in inflammation.
2006 Sep
[Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy].
2007
Heparan sulphate proteoglycans fine-tune mammalian physiology.
2007 Apr 26
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.
2007 Jul 18
Patents

Patents

03931143
17
03931217
10
03931218
7
03931239
39
03931412
37
03932479
112
03932483
74
03932505
8
03932630
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03939185
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03940407
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03940411
9
03943151
7
03943154
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03946008
8
03947582
12
03966830
12
03983253
7
03992189
8
04001300
7
04013695
7
04016182
7
04028419
7
04036979
10
04049659
8
04052511
8
04055602
7
04061771
12
04066543
7
04073798
8
04078006
9
04086278
7
04086338
8
04105776
10
04124601
7
04128653
7
04154840
19
04154937
7
04156670
8
04160657
7
04164543
14
04171447
7
04190433
7
04191830
8
04205178
7
04229207
7
04242265
8
04273704
7
04278808
7
04324729
7
04337197
7
04340415
7
04340747
7
04342737
7
04350633
9
04351846
7
04355105
7
04395414
8
04396772
7
04401808
8
04453013
8
04454291
7
04454292
7
04461896
16
04477369
7
04533660
37
04536402
7
04549019
10
04565882
8
04611002
7
04613463
35
04621078
7
04657700
7
04690936
10
04692458
8
04711895
8
04734420
73
04736057
8
04745124
8
04751018
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04760161
8
04764512
7
04778790
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04788010
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04831153
7
04889859
9
04894458
12
04931568
7
04954278
7
04954328
8
05112863
7
05232624
7
05401621
7
06071927
10
06110491
7
06528526
7
07932007
7
07932354
7

Sample Use Guides

In Vivo Use Guide
Split-Dose (2-Day) Regimen: The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour. Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.
Route of Administration: Oral
Name Type Language
Potassium sulfate
EP   FCC   HSDB   INCI   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
USAN   INCI  
Official Name English
POTASSIUM SULFATE [JAN]
Common Name English
BLI801 Component Potassium sulfate
Common Name English
POTASSIUM SULFATE [MI]
Common Name English
POTASSIUM SULFATE COMPONENT OF SUPREP BOWEL PREP KIT
Common Name English
INS-515(I)
Code English
E-515(I)
Code English
INS NO.515(I)
Code English
ARCANUM DUPLICATUM
Common Name English
POTASSIUM SULFATE [EP MONOGRAPH]
Common Name English
POTASSIUM SULFATE [USAN]
Common Name English
POTASSIUM SULPHATE
Systematic Name English
KALI SULPHURICUM
HPUS  
Common Name English
POTASSIUM SULFATE [INCI]
Common Name English
KALI SULPHURICUM [HPUS]
Common Name English
Potassium sulfate [WHO-DD]
Common Name English
BLI-801 Component Potassium sulfate
Common Name English
DIPOTASSIUM SULFATE
Systematic Name English
POTASSIUM SULFATE [MART.]
Common Name English
POTASSIUM SULFATE [ORANGE BOOK]
Common Name English
SULFURIC ACID POTASSIUM SALT (1:2)
Common Name English
SULFURIC ACID, DIPOTASSIUM SALT
Common Name English
POTASSIUM SULFATE [HSDB]
Common Name English
POTASSIUM (AS SULFATE) [VANDF]
Common Name English
SAL POLYCHRESTUM
Common Name English
POTASSIUM SULFATE [VANDF]
Common Name English
TARTARUS VITRIOLATUS
Common Name English
SUPREP BOWEL PREP KIT COMPONENT POTASSIUM SULFATE
Common Name English
POTASSIUM SULFATE [FCC]
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-515(I)
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
EPA PESTICIDE CODE 5603
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
DSLD 3829 (Number of products:3)
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
FDA ORPHAN DRUG 403513
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
FDA ORPHAN DRUG 379212
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-515(I)
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
CFR 21 CFR 184.1643
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
Code System Code Type Description
EVMPD
SUB20370
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
DRUG BANK
DB14499
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
EPA CompTox
DTXSID6029701
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
CONCEPT Industrial Aid
DAILYMED
1K573LC5TV
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
NCI_THESAURUS
C80907
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
FDA UNII
1K573LC5TV
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
USAN
WW-45
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
RXCUI
34323
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY RxNorm
CAS
7778-80-5
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
CHEBI
32036
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
HSDB
5047
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
WIKIPEDIA
POTASSIUM SULFATE
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
SMS_ID
100000089071
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-915-5
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL2021424
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
PUBCHEM
24507
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
MERCK INDEX
m9063
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY Merck Index
MESH
C031512
Created by admin on Fri Dec 15 15:57:45 GMT 2023 , Edited by admin on Fri Dec 15 15:57:45 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of SULFATE ION
SUBSTANCE RECORD
Structure of Potassium sulfate
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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