DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/17878146
Sources: http://www.ncbi.nlm.nih.gov/pubmed/17878146
Polymyxin B is a lipopeptide antibiotic isolated from Bacillus polymyxa. Its basic structure consists of a polycationic peptide ring and a tripeptide side chain with a fatty acid tail. Polymyxin B is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B acts on Gram-negative bacteria by interacting with lipopolysaccharide (LPS) of the outer membrane and destabilizing it. Polymyxin B is indicated for the treatment of many bacterial diseases such as meningeal infections, urinary tract infections and bacteremia.
CNS Activity
Sources: http://www.ncbi.nlm.nih.gov/pubmed/19202043
Curator's Comment: Polymyxin B penetrates BBB and cause neurotoxic effect.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: Q28824 Gene ID: 338037.0 Gene Symbol: MYLK Target Organism: Bos taurus (Bovine) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1847132 |
70.0 µM [IC50] | ||
Target ID: Protein kinase C (Bos taurus) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1847132 |
4.0 µM [IC50] | ||
Target ID: Na,K-ATPase (rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1847132 |
800.0 µM [IC50] | ||
Target ID: GO:0043165 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | POLYMYXIN B SULFATE Approved UseAcute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date1964 |
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Curative | POLYMYXIN B SULFATE Approved UseAcute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date1964 |
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Curative | POLYMYXIN B SULFATE Approved UseAcute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date1964 |
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Curative | POLYMYXIN B SULFATE Approved UseAcute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date1964 |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: 25,000 to 30,000 units/kg/day (Intramuscular injection), 50,000 units once daily intrathecally for 3 to 4 days, then 50,000 units once every other day for at least 2 weeks (Intrathecal injection).
15,000 to 25,000 units/kg body weight/day
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1195418/
Polymyxin B MICs were determined for different strains of P. aeruginosa in Ca-MHB using a broth macrodilution method. The MIC was defined as the lowest concentration of drug that resulted in no visible growth after 24 h of incubation at 35°C in ambient air. The polymyxin B MIC ranged from 0.5 to 1 mg/liter.
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Classification Tree | Code System | Code | ||
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CFR |
21 CFR 333.120
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NCI_THESAURUS |
C78160
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SUB03938MIG
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m8963
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DB00781
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C61895
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All of the following components must be present:
ACTIVE MOIETY
SUBSTANCE RECORD