POLYMYXIN B

US Approved OTC

First approved in 1951

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/17878146

Polymyxin B is a lipopeptide antibiotic isolated from Bacillus polymyxa. Its basic structure consists of a polycationic peptide ring and a tripeptide side chain with a fatty acid tail. Polymyxin B is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B acts on Gram-negative bacteria by interacting with lipopolysaccharide (LPS) of the outer membrane and destabilizing it. Polymyxin B is indicated for the treatment of many bacterial diseases such as meningeal infections, urinary tract infections and bacteremia.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Potency
Myosin light chain kinase, smooth muscle 6 Target ID: Q28824 Gene ID: 338037.0 Gene Symbol: MYLK Target Organism: Bos taurus (Bovine) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1847132	Inhibitor 8297	70.0 µM [IC50]
Protein kinase C (Bos taurus) 2 Target ID: Protein kinase C (Bos taurus) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1847132	Inhibitor 8297	4.0 µM [IC50]
Na,K-ATPase (rat) 2 Target ID: Na,K-ATPase (rat) Sources: https://www.ncbi.nlm.nih.gov/pubmed/1847132	Inhibitor 8297	800.0 µM [IC50]
Gram-negative-bacterium-type cell outer membrane assembly 2 Target ID: GO:0043165 Sources: http://watcut.uwaterloo.ca/webnotes/Pharmacology/microbesBacterialMembranes.html	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Acute Infections due to Pseudomonas aeruginosa 2 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf	Curative	Approved 8429	POLYMYXIN B SULFATE Approved Use Acute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date 1964
Meningeal infections due to H influenzae 2 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf	Curative	Approved 8429	POLYMYXIN B SULFATE Approved Use Acute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date 1964
Urinary tract infections, E.coli 2 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf	Curative	Approved 8429	POLYMYXIN B SULFATE Approved Use Acute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date 1964
Sepsis 71 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/060716Orig1s020Lbl.pdf	Curative	Approved 8429	POLYMYXIN B SULFATE Approved Use Acute infections caused by susceptible strains of Pseudomonas aeruginosa. Launch Date 1964

PubMed

Title	Date	PubMed
LABORATORY AND CLINICAL STUDIES OF POLYMYXIN B AND E.	1949 Sep	16695740
Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria.	2008 Oct	18949034
Evolution and dynamics of regulatory architectures controlling polymyxin B resistance in enteric bacteria.	2008 Oct	18949034
Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.	2015 Nov 13	27525307
A feed-forward loop between SroC and MgrR small RNAs modulates the expression of eptB and the susceptibility to polymyxin B in Salmonella Typhimurium.	2016 Nov	27571709

Patents

Sample Use Guides

In Vivo Use Guide

15,000 to 25,000 units/kg body weight/day

Route of Administration: Intravenous

In Vitro Use Guide

Polymyxin B MICs were determined for different strains of P. aeruginosa in Ca-MHB using a broth macrodilution method. The MIC was defined as the lowest concentration of drug that resulted in no visible growth after 24 h of incubation at 35°C in ambient air. The polymyxin B MIC ranged from 0.5 to 1 mg/liter.

Substance Class	Mixture Created by `admin` on `Fri Dec 15 15:51:09 GMT 2023` Edited by `admin` on `Fri Dec 15 15:51:09 GMT 2023`
Record UNII	J2VZ07J96K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POLYMYXIN B

Official Name

English

POLYMYXIN B [VANDF]

Common Name

English

polymyxin b [INN]

Common Name

English

Polymyxin b [WHO-DD]

Common Name

English

POLYMYXIN B [MI]

Common Name

English

POLYSPORIN COMPONENT POLYMYXIN B

Brand Name

English

POLYMIXIN B

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000007822