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Description

Polymyxin B is a lipopeptide antibiotic isolated from Bacillus polymyxa. Its basic structure consists of a polycationic peptide ring and a tripeptide side chain with a fatty acid tail. Polymyxin B is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B acts on Gram-negative bacteria by interacting with lipopolysaccharide (LPS) of the outer membrane and destabilizing it. Polymyxin B is indicated for the treatment of many bacterial diseases such as meningeal infections, urinary tract infections and bacteremia.

CNS Activity

CNS Active
3913
Curator's Comment: Polymyxin B penetrates BBB and cause neurotoxic effect.

Approval Year

1951
104
Targets

Targets

Primary TargetPharmacologyConditionPotency
Myosin light chain kinase, smooth muscle
6
Target ID: Q28824
Gene ID: 338037.0
Gene Symbol: MYLK
Target Organism: Bos taurus (Bovine)
Inhibitor
8297
 70.0 µM [IC50]
Protein kinase C (Bos taurus)
2
Target ID: Protein kinase C (Bos taurus)
Inhibitor
8297
 4.0 µM [IC50]
Inhibitor
8297
 800.0 µM [IC50]
Binding Agent
1064
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
POLYMYXIN B SULFATE

Approved Use

Acute infections caused by susceptible strains of Pseudomonas aeruginosa.

Launch Date

-1.73836796E11
Curative
Approved
8429
POLYMYXIN B SULFATE

Approved Use

Acute infections caused by susceptible strains of Pseudomonas aeruginosa.

Launch Date

-1.73836796E11
Curative
Approved
8429
POLYMYXIN B SULFATE

Approved Use

Acute infections caused by susceptible strains of Pseudomonas aeruginosa.

Launch Date

-1.73836796E11
Curative
Approved
8429
POLYMYXIN B SULFATE

Approved Use

Acute infections caused by susceptible strains of Pseudomonas aeruginosa.

Launch Date

-1.73836796E11
PubMed

PubMed

TitleDatePubMed
COMPARISON OF THE ACTION OF STREPTOMYCIN, POLYMYXIN B, AUREOMYCIN AND CHLOROMYCETIN ON H. PERTUSSIS, H. PARAPERTUSSIS, H. INFLUENZAE AND FIVE ENTERIC STRAINS OF GRAM-NEGATIVE BACILLI.
1949 Sep
LABORATORY AND CLINICAL STUDIES OF POLYMYXIN B AND E.
1949 Sep
Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.
2015 Nov 13
Polymyxin B Nephrotoxicity: From Organ to Cell Damage.
2016
Polymyxin-B hemoperfusion in septic patients: analysis of a multicenter registry.
2016 Dec
Successful treatments with polymyxin B hemoperfusion and recombinant human thrombomodulin for fulminant Clostridium difficile-associated colitis with septic shock and disseminated intravascular coagulation: a case report.
2016 Dec
The effects of direct hemoperfusion using a polymyxin B-immobilized column in a pig model of severe Pseudomonas aeruginosa pneumonia.
2016 Dec
A feed-forward loop between SroC and MgrR small RNAs modulates the expression of eptB and the susceptibility to polymyxin B in Salmonella Typhimurium.
2016 Nov
Patents

Patents

04661260
68
04771104
2

Sample Use Guides

In Vivo Use Guide
Curator's Comment: 25,000 to 30,000 units/kg/day (Intramuscular injection), 50,000 units once daily intrathecally for 3 to 4 days, then 50,000 units once every other day for at least 2 weeks (Intrathecal injection).
15,000 to 25,000 units/kg body weight/day
Route of Administration: Intravenous
In Vitro Use Guide
Polymyxin B MICs were determined for different strains of P. aeruginosa in Ca-MHB using a broth macrodilution method. The MIC was defined as the lowest concentration of drug that resulted in no visible growth after 24 h of incubation at 35°C in ambient air. The polymyxin B MIC ranged from 0.5 to 1 mg/liter.
Substance Class Mixture
Created
by admin
on Fri Dec 15 15:50:08 UTC 2023
Edited
by admin
on Fri Dec 15 15:50:08 UTC 2023
Record UNII
19371312D4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Polymyxin B sulfate
GREEN BOOK   MI   ORANGE BOOK   USP   VANDF   WHO-DD  
Common Name English
STATROL COMPONENT POLYMYXIN B SULFATE
Common Name English
AEROSPORIN
Brand Name English
POLYMYXIN B SULFATE COMPONENT OF LANABIOTIC
Common Name English
POLYMIXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF STATROL
Common Name English
PEDIOTIC COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF OCUMYCIN
Common Name English
POLYMYXIN B SULFATE COMPONENT OF POLY-PRED
Common Name English
POLYMYXIN B SULFATE [USP MONOGRAPH]
Common Name English
POLYMYXIN B SULFATE COMPONENT OF OTOBIONE
Common Name English
OPHTHOCORT COMPONENT POLYMYXIN B SULFATE
Common Name English
OCUMYCIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMIXIN B SULFATE [JAN]
Common Name English
PYOCIDIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF POLYSPORIN
Common Name English
MYCITRACIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B, SULPHATE
Common Name English
OTOBIOTIC COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF OTICAIR
Common Name English
NSC-757278
Code English
OTOBIONE COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYTRIM COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF OPHTHOCORT
Common Name English
LANABIOTIC COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF OTOBIOTIC
Common Name English
Polymyxin b sulfate [WHO-DD]
Common Name English
POLYMYXIN B SULFATE [ORANGE BOOK]
Common Name English
POLYMYXIN B SULFATE COMPONENT OF DEXACIDIN
Common Name English
POLYMYXIN B SULFATE [GREEN BOOK]
Common Name English
POLYMYXIN B, SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF MAXITROL
Common Name English
CHLOROMYXIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF NEO-POLYCIN
Common Name English
POLYMYXIN B SULFATE COMPONENT OF PYOCIDIN
Common Name English
POLY-PRED COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF POLYTRIM
Common Name English
POLY-RX
Brand Name English
POLYMYXIN B SULPHATE
Common Name English
NEO-POLYCIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYSPORIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF CHLOROMYXIN
Common Name English
OTICAIR COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF PEDIOTIC
Common Name English
OTOCORT COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE [EP MONOGRAPH]
Common Name English
MAXITROL COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE [USP IMPURITY]
Common Name English
POLYMYXIN B SULFATE COMPONENT OF DEXASPORIN
Common Name English
POLYMIXIN B SULPHATE
Common Name English
POLYMYCIN B SULFATE
Common Name English
POLYMYXIN B SULFATE COMPONENT OF OTOCORT
Common Name English
POLYMYXIN B SULFATE [USP-RS]
Common Name English
DEXACIDIN COMPONENT POLYMYXIN B SULFATE
Common Name English
DEXASPORIN COMPONENT POLYMYXIN B SULFATE
Common Name English
POLYMYXIN B SULFATE [VANDF]
Common Name English
POLYMYXIN B SULFATE COMPONENT OF MYCITRACIN
Common Name English
POLYMYXIN B SULFATE [MI]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 333.120
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
NCI_THESAURUS C78160
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL1201283
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
EVMPD
SUB03938MIG
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
ECHA (EC/EINECS)
215-774-7
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
DAILYMED
19371312D4
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
RS_ITEM_NUM
1547007
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
NSC
757278
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
CAS
1405-20-5
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
EPA CompTox
DTXSID5045839
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
RXCUI
388
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY RxNorm
FDA UNII
19371312D4
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
MERCK INDEX
m8963
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY Merck Index
DRUG BANK
DB00781
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
NCI_THESAURUS
C61895
Created by admin on Fri Dec 15 15:50:08 UTC 2023 , Edited by admin on Fri Dec 15 15:50:08 UTC 2023
PRIMARY
All of the following components must be present:
Structure of POLYMYXIN B1 SULFATE
Structure of POLYMYXIN B1-I SULFATE
Structure of POLYMYXIN B3 SULFATE
Structure of POLYMYXIN B2 SULFATE
Related Record Type Details
POLYMYXIN B
ACTIVE MOIETY
Definition References
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NCATS
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