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Details

Stereochemistry ACHIRAL
Molecular Formula C22H30N2O2
Molecular Weight 354.4858
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BARUCAINIDE

SMILES

CC(C)NCCCCOC1=C2COCC2=C(CC3=CC=CC=C3)N=C1C

InChI

InChIKey=KXSKBNFNSAMNEZ-UHFFFAOYSA-N
InChI=1S/C22H30N2O2/c1-16(2)23-11-7-8-12-26-22-17(3)24-21(19-14-25-15-20(19)22)13-18-9-5-4-6-10-18/h4-6,9-10,16,23H,7-8,11-15H2,1-3H3

HIDE SMILES / InChI

Description

Barucainide, an IB anti-arrhythmic agent, was evaluated in patients with coronary artery disease. Its antiarrhythmic effect was studied in patients with markedly depressed left-ventricular function. Barucainide was in phase II clinical trials to treat the patients with arrhythmias but the development of the drug was discontinued.

Originator

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
The pharmacokinetic behavior of the class Ib antiarrhythmic drug barucainide was investigated in a phase I study in a group of 6 healthy male volunteers after oral administration of an initial single dose of 20 mg and incremental doses between 30 and 70 mg barucainide hydrochloride.
Route of Administration: Oral