BARUCAINIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H30N2O2
Molecular Weight	354.4858
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCCCCOC1=C2COCC2=C(CC3=CC=CC=C3)N=C1C

InChI

InChIKey=KXSKBNFNSAMNEZ-UHFFFAOYSA-N

InChI=1S/C22H30N2O2/c1-16(2)23-11-7-8-12-26-22-17(3)24-21(19-14-25-15-20(19)22)13-18-9-5-4-6-10-18/h4-6,9-10,16,23H,7-8,11-15H2,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1294860 | https://adisinsight.springer.com/drugs/800000197

Barucainide, an IB anti-arrhythmic agent, was evaluated in patients with coronary artery disease. Its antiarrhythmic effect was studied in patients with markedly depressed left-ventricular function. Barucainide was in phase II clinical trials to treat the patients with arrhythmias but the development of the drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Effect of barucainide on left ventricular ejection fraction in patients with ventricular cardiac arrhythmias].	1991 Oct	1722935
Investigation of the pharmacokinetic behavior of barucainide in man during an early phase I study.	1992 Nov	1294860

Patents

Sample Use Guides

In Vivo Use Guide

The pharmacokinetic behavior of the class Ib antiarrhythmic drug barucainide was investigated in a phase I study in a group of 6 healthy male volunteers after oral administration of an initial single dose of 20 mg and incremental doses between 30 and 70 mg barucainide hydrochloride.

Route of Administration: Oral

Name

Type

Language

BARUCAINIDE

Official Name

English

BARUCAINIDE [MART.]

Common Name

English

4-BENZYL-1,3-DIHYDRO-7-(4-(ISOPROPYLAMINO)BUTOXY)-6-METHYLFURO(3,4-C)PYRIDINE

Systematic Name

English

barucainide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793