Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H30N2O2 |
| Molecular Weight | 354.4858 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NCCCCOC1=C2COCC2=C(CC3=CC=CC=C3)N=C1C
InChI
InChIKey=KXSKBNFNSAMNEZ-UHFFFAOYSA-N
InChI=1S/C22H30N2O2/c1-16(2)23-11-7-8-12-26-22-17(3)24-21(19-14-25-15-20(19)22)13-18-9-5-4-6-10-18/h4-6,9-10,16,23H,7-8,11-15H2,1-3H3
Barucainide, an IB anti-arrhythmic agent, was evaluated in patients with coronary artery disease. Its antiarrhythmic effect was studied in patients with markedly depressed left-ventricular function. Barucainide was in phase II clinical trials to treat the patients with arrhythmias but the development of the drug was discontinued.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Investigation of the pharmacokinetic behavior of barucainide in man during an early phase I study. | 1992-11 |
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| [Effect of barucainide on left ventricular ejection fraction in patients with ventricular cardiac arrhythmias]. | 1991-10 |
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| Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle. | 1990-05 |
Patents
Sample Use Guides
The pharmacokinetic behavior of the class Ib antiarrhythmic drug barucainide was investigated in a phase I study in a group of 6 healthy male volunteers after oral administration of an initial single dose of 20 mg and incremental doses between 30 and 70 mg barucainide hydrochloride.
Route of Administration:
Oral
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NCI_THESAURUS |
C47793
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
