BARUCAINIDE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H30N2O2.ClH
Molecular Weight	390.947
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCCCCOC1=C2COCC2=C(CC3=CC=CC=C3)N=C1C

InChI

InChIKey=NDUAUQZNHSFJMY-UHFFFAOYSA-N

InChI=1S/C22H30N2O2.ClH/c1-16(2)23-11-7-8-12-26-22-17(3)24-21(19-14-25-15-20(19)22)13-18-9-5-4-6-10-18;/h4-6,9-10,16,23H,7-8,11-15H2,1-3H3;1H

HIDE SMILES / InChI

Molecular Formula	C22H30N2O2
Molecular Weight	354.4858
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1294860 | https://adisinsight.springer.com/drugs/800000197

Barucainide, an IB anti-arrhythmic agent, was evaluated in patients with coronary artery disease. Its antiarrhythmic effect was studied in patients with markedly depressed left-ventricular function. Barucainide was in phase II clinical trials to treat the patients with arrhythmias but the development of the drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Investigation of the pharmacokinetic behavior of barucainide in man during an early phase I study.	1992-11	1294860
[Effect of barucainide on left ventricular ejection fraction in patients with ventricular cardiac arrhythmias].	1991-10	1722935
Barucainide, a novel class Ib antiarrhythmic agent with a slow kinetic property: electrophysiologic observations in isolated canine and rabbit cardiac muscle.	1990-05	2330863

Patents

Sample Use Guides

In Vivo Use Guide

The pharmacokinetic behavior of the class Ib antiarrhythmic drug barucainide was investigated in a phase I study in a group of 6 healthy male volunteers after oral administration of an initial single dose of 20 mg and incremental doses between 30 and 70 mg barucainide hydrochloride.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:50:14 GMT 2025` Edited by `admin` on `Mon Mar 31 17:50:14 GMT 2025`
Record UNII	RFI1WXG626
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BARUCAINIDE HYDROCHLORIDE

Common Name

English

1-BUTANAMINE, 4-((1,3-DIHYDRO-6-METHYL-4-(PHENYLMETHYL)FURO(3,4-C)PYRIDIN-7-YL)OXY)-N-(1-METHYLETHYL)-, HYDROCHLORIDE (1:1)

Preferred Name

English

4-((1,3-DIHYDRO-6-METHYL-4-(PHENYLMETHYL)FURO(3,4-C)PYRIDIN-7-YL)OXY)-N-(1-METHYLETHYL)-1-BUTANAMINE HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

301-208-7