EPIRIZOLE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H14N4O2.ClH
Molecular Weight	270.715
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC(C)=NN1C2=NC(OC)=CC(C)=N2

InChI

InChIKey=YJVOCLSBUGKSCI-UHFFFAOYSA-N

InChI=1S/C11H14N4O2.ClH/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15;/h5-6H,1-4H3;1H

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Description
Sources: http://jikm.or.kr/upload/pdf/200103/04-%EA%B9%80%EC%9B%90%EC%9D%BC%20.pdf

Epirizole (also known as Mepirizole) is a nonsteroidal anti-inflammatory drug developed for the treatment of such conditions as chronic rheumatoid arthritis. Although the drug was tested in a clinical trial, its current status is unknown and is supposed to be discontinued. Epirizole is known to be a duodenal ulcerogen, and its effect is mediated by generation of ROS.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic rheumatoid arthritis 4 Sources: http://www.ncbi.nlm.nih.gov/pubmed/4581124	Palliative		Phase II 1132	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Synthesis, crystal structure, magnetic properties, and theoretical studies of [(Cu(mepirizole)Br)2(mu-OH)(mu-pz)] (mepirizole=4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine; pz=pyrazolate), a novel mu-pyrazolato-mu-hydroxo-dibridged copper(II) complex.	2003 Dec 15	14658885
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.	2004	15146935

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

EPIRIZOLE HYDROCHLORIDE

Common Name

English

Epirizole hydrochloride [WHO-DD]

Common Name

English

4-METHOXY-2-(5-METHOXY-3-METHYLPYRAZOL-1-YL)-6-METHYLPYRIMIDINE HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

138HY1BQ0T