EPIRIZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H14N4O2
Molecular Weight	234.2545
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(C)=NN1C2=NC(OC)=CC(C)=N2

InChI

InChIKey=RHAXSHUQNIEUEY-UHFFFAOYSA-N

InChI=1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3

HIDE SMILES / InChI

Molecular Formula	C11H14N4O2
Molecular Weight	234.2545
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://jikm.or.kr/upload/pdf/200103/04-%EA%B9%80%EC%9B%90%EC%9D%BC%20.pdf

Epirizole (also known as Mepirizole) is a nonsteroidal anti-inflammatory drug developed for the treatment of such conditions as chronic rheumatoid arthritis. Although the drug was tested in a clinical trial, its current status is unknown and is supposed to be discontinued. Epirizole is known to be a duodenal ulcerogen, and its effect is mediated by generation of ROS.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic rheumatoid arthritis 4 Sources: http://www.ncbi.nlm.nih.gov/pubmed/4581124	Palliative		Phase II 1132	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Study of the modifications caused by cisplatin, transplatin, and Pd(II) and Pt(II) mepirizole derivatives on pBR322 DNA by atomic force microscopy.	2002 Oct 1	12270242
Synthesis, crystal structure, magnetic properties, and theoretical studies of [(Cu(mepirizole)Br)2(mu-OH)(mu-pz)] (mepirizole=4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine; pz=pyrazolate), a novel mu-pyrazolato-mu-hydroxo-dibridged copper(II) complex.	2003 Dec 15	14658885
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.	2004	15146935

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:02:16 GMT 2023` Edited by `admin` on `Fri Dec 15 15:02:16 GMT 2023`
Record UNII	3B46O2FH8I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPIRIZOLE

Official Name

English

EPIRIZOLE [MI]

Common Name

English

EPIRIZOLE [JAN]

Common Name

English

epirizole [INN]

Common Name

English

EPIRIZOLE [USAN]

Common Name

English

EPIRIZOLE [MART.]

Common Name

English

DA-398

Code

English

Epirizole [WHO-DD]

Common Name

English

MEPIRIZOLE

Common Name

English

MEBRON

Brand Name

English

METHOPYRIMAZOLE

Common Name

English

PYRIMIDINE, 4-METHOXY-2-(5-METHOXY-3-METHYL-1H-PYRAZOL-1-YL)-6-METHYL-

Systematic Name

English

4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine

Systematic Name

English

2-(3-METHYL-5-METHOXY-1-PYRAZOLYL)-4-METHOXY-6-METHYL-PYRIMIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257