EPIRIZOLE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H14N4O2.ClH
Molecular Weight	270.715
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=CC(C)=NN1C2=NC(OC)=CC(C)=N2

InChI

InChIKey=YJVOCLSBUGKSCI-UHFFFAOYSA-N

InChI=1S/C11H14N4O2.ClH/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15;/h5-6H,1-4H3;1H

HIDE SMILES / InChI

Molecular Formula	C11H14N4O2
Molecular Weight	234.2545
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://jikm.or.kr/upload/pdf/200103/04-%EA%B9%80%EC%9B%90%EC%9D%BC%20.pdf

Epirizole (also known as Mepirizole) is a nonsteroidal anti-inflammatory drug developed for the treatment of such conditions as chronic rheumatoid arthritis. Although the drug was tested in a clinical trial, its current status is unknown and is supposed to be discontinued. Epirizole is known to be a duodenal ulcerogen, and its effect is mediated by generation of ROS.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic rheumatoid arthritis 4 Sources: http://www.ncbi.nlm.nih.gov/pubmed/4581124	Palliative		Phase II 1132	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Study of the modifications caused by cisplatin, transplatin, and Pd(II) and Pt(II) mepirizole derivatives on pBR322 DNA by atomic force microscopy.	2002 Oct 1	12270242
Synthesis, crystal structure, magnetic properties, and theoretical studies of [(Cu(mepirizole)Br)2(mu-OH)(mu-pz)] (mepirizole=4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine; pz=pyrazolate), a novel mu-pyrazolato-mu-hydroxo-dibridged copper(II) complex.	2003 Dec 15	14658885
Gastric antisecretory and anti-ulcer effect of ME3407, a new benzimidazole derivative, in rats.	2004	15146935

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:55:53 GMT 2023` Edited by `admin` on `Sat Dec 16 01:55:53 GMT 2023`
Record UNII	138HY1BQ0T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPIRIZOLE HYDROCHLORIDE

Common Name

English

Epirizole hydrochloride [WHO-DD]

Common Name

English

4-METHOXY-2-(5-METHOXY-3-METHYLPYRAZOL-1-YL)-6-METHYLPYRIMIDINE HYDROCHLORIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

138HY1BQ0T