Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H35N3O6 |
| Molecular Weight | 497.5833 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCC1=CC=C(C=C1)C2=CC3=CN([C@H]4C[C@H](O)[C@@H](COC(=O)[C@@H](N)C(C)C)O4)C(=O)N=C3O2
InChI
InChIKey=FJRRWJMFUNGZBJ-RBVMOCNTSA-N
InChI=1S/C27H35N3O6/c1-4-5-6-7-17-8-10-18(11-9-17)21-12-19-14-30(27(33)29-25(19)36-21)23-13-20(31)22(35-23)15-34-26(32)24(28)16(2)3/h8-12,14,16,20,22-24,31H,4-7,13,15,28H2,1-3H3/t20-,22+,23+,24-/m0/s1
Valnivudine, also known as FV-100, a prodrug that has been indicated as a potential antiviral for the treatment of shingles (herpes zoster) that could both reduce the pain burden of the acute episode and reduce the incidence of post‐herpetic neuralgia compared to available treatments. Phase I clinical trial with FV100 showed safety and tolerability in healthy volunteers. Valnivudine also participated in phase III, where its efficacy was compared with valacyclovir; however, the study was terminated.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Highly potent and selective inhibition of varicella-zoster virus by bicyclic furopyrimidine nucleosides bearing an aryl side chain. | 2000 Dec 28 |
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| Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility. | 2002 Mar |
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| Bicyclic nucleoside inhibitors of varicella-zoster virus: effect of terminal aryl substitution in the side-chain. | 2002 Sep |
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| FV-100: the most potent and selective anti-varicella zoster virus agent reported to date. | 2010 Jan 5 |
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| FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial. | 2017 Jul |
Patents
| Name | Type | Language | ||
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Official Name | English | ||
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Code | English | ||
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C1557
Created by
admin on Sat Dec 16 05:41:35 GMT 2023 , Edited by admin on Sat Dec 16 05:41:35 GMT 2023
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NCI_THESAURUS |
C281
Created by
admin on Sat Dec 16 05:41:35 GMT 2023 , Edited by admin on Sat Dec 16 05:41:35 GMT 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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DTXSID30241909
Created by
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PRIMARY | |||
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C152817
Created by
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PRIMARY | |||
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FV-100
Created by
admin on Sat Dec 16 05:41:35 GMT 2023 , Edited by admin on Sat Dec 16 05:41:35 GMT 2023
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10397
Created by
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100000174659
Created by
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PRIMARY | |||
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16063377
Created by
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PRIMARY | |||
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956483-02-6
Created by
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0NJ5F6D4U7
Created by
admin on Sat Dec 16 05:41:35 GMT 2023 , Edited by admin on Sat Dec 16 05:41:35 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SUBSTANCE RECORD
