Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H35N3O6.ClH |
| Molecular Weight | 534.044 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCCCC1=CC=C(C=C1)C2=CC3=CN([C@H]4C[C@H](O)[C@@H](COC(=O)[C@@H](N)C(C)C)O4)C(=O)N=C3O2
InChI
InChIKey=CAHTYTZOAVUCIU-ZMQZINMSSA-N
InChI=1S/C27H35N3O6.ClH/c1-4-5-6-7-17-8-10-18(11-9-17)21-12-19-14-30(27(33)29-25(19)36-21)23-13-20(31)22(35-23)15-34-26(32)24(28)16(2)3;/h8-12,14,16,20,22-24,31H,4-7,13,15,28H2,1-3H3;1H/t20-,22+,23+,24-;/m0./s1
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C27H35N3O6 |
| Molecular Weight | 497.5833 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Valnivudine, also known as FV-100, a prodrug that has been indicated as a potential antiviral for the treatment of shingles (herpes zoster) that could both reduce the pain burden of the acute episode and reduce the incidence of post‐herpetic neuralgia compared to available treatments. Phase I clinical trial with FV100 showed safety and tolerability in healthy volunteers. Valnivudine also participated in phase III, where its efficacy was compared with valacyclovir; however, the study was terminated.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Novel aryl substituted bicyclic furo nucleosides as extremely potent and selective anti-VZV agents. | 2001 Apr-Jul |
|
| Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues. | 2003 May |
|
| Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues. | 2004 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:00:30 GMT 2023
by
admin
on
Sat Dec 16 05:00:30 GMT 2023
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| Record UNII |
L4N5F436FO
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| Record Status |
Validated (UNII)
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| Record Version |
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71587897
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DTXSID40241910
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956483-03-7
Created by
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L4N5F436FO
Created by
admin on Sat Dec 16 05:00:30 GMT 2023 , Edited by admin on Sat Dec 16 05:00:30 GMT 2023
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
