Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H26N2O5 |
| Molecular Weight | 398.4522 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCC1=CC=C(C=C1)C2=CC3=CN([C@H]4C[C@H](O)[C@@H](CO)O4)C(=O)N=C3O2
InChI
InChIKey=MFGSDSRTGUVZQG-DFQSSKMNSA-N
InChI=1S/C22H26N2O5/c1-2-3-4-5-14-6-8-15(9-7-14)18-10-16-12-24(22(27)23-21(16)29-18)20-11-17(26)19(13-25)28-20/h6-10,12,17,19-20,25-26H,2-5,11,13H2,1H3/t17-,19+,20+/m0/s1
| Molecular Formula | C22H26N2O5 |
| Molecular Weight | 398.4522 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Valnivudine, also known as FV-100, a prodrug that has been indicated as a potential antiviral for the treatment of shingles (herpes zoster) that could both reduce the pain burden of the acute episode and reduce the incidence of post‐herpetic neuralgia compared to available treatments. Phase I clinical trial with FV100 showed safety and tolerability in healthy volunteers. Valnivudine also participated in phase III, where its efficacy was compared with valacyclovir; however, the study was terminated.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides. | 2002 Jul 18 |
|
| Alkyloxyphenyl furano pyrimidines as potent and selective anti-VZV agents with enhanced water solubility. | 2002 Mar |
|
| Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues. | 2004 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:37:25 UTC 2023
by
admin
on
Sat Dec 16 04:37:25 UTC 2023
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| Record UNII |
5XGI48Q2DH
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| Record Status |
Validated (UNII)
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| Record Version |
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319425-66-6
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493485
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5XGI48Q2DH
Created by
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DTXSID60185781
Created by
admin on Sat Dec 16 04:37:25 UTC 2023 , Edited by admin on Sat Dec 16 04:37:25 UTC 2023
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PRODRUG -> METABOLITE ACTIVE |
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ACTIVE MOIETY |
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