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Details

Stereochemistry ACHIRAL
Molecular Formula C6H12N2S4
Molecular Weight 240.433
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THIRAM

SMILES

CN(C)C(=S)SSC(=S)N(C)C

InChI

InChIKey=KUAZQDVKQLNFPE-UHFFFAOYSA-N
InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3

HIDE SMILES / InChI

Description

Thiram is a pesticide, It is used as a fungicide, ectoparasiticide to prevent fungal diseases in seed and crops. It is also used as an animal repellent to protect fruit trees and ornamentals from damage by rabbits, rodents and deer. Thiram belongs to the ethylene bisdithiocarbamate (EBDC) chemical class. It is available as dust, flowable, wettable powder, water dispersible granules, and water suspension formulations and in mixtures with other fungicides. Thiram has been used in the treatment of human scabies, as a sun screen and as a bactericide applied directly to the skin or incorporated into soap. Thiram is a skin sensitizer. It is moderately toxic by ingestion, but it is highly toxic if inhaled. Acute exposure in humans may cause headaches, dizziness, fatigue, nausea, diarrhea and other gastrointestinal complaints. In rats and mice, large doses of thiram produced muscle incoordination, hyperactivity followed by inactivity, loss of muscular tone, labored breathing, convulsions and death.

CNS Activity

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The chondrocytes, isolated from proximal tibial growth plates of 2-week old chickens, were cultured with or without a sub-lethal (1 uM) concentration of thiram for 48 hr