U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Al.K.2O4S
Molecular Weight 258.205
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of POTASSIUM ALUM ANHYDROUS

SMILES

[Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=GRLPQNLYRHEGIJ-UHFFFAOYSA-J
InChI=1S/Al.K.2H2O4S/c;;2*1-5(2,3)4/h;;2*(H2,1,2,3,4)/q+3;+1;;/p-4

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Curator's Comment: Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMEBORO

Approved Use

Temporarily relieves minor skin irritations due to: – Poison ivy | – Poison oak – Poison sumac | – Insect bites – Athlete’s foot | – Rashes caused by soaps, detergents, cosmetics, or jewelry
Curative
DOMEBORO

Approved Use

This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.
PubMed

PubMed

TitleDatePubMed
Aluminum inclusion macrophagic myofasciitis: a recently identified condition.
2003 Nov
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].
2004 Nov
Aluminum and Alzheimer's disease, a personal perspective after 25 years.
2006
Aluminum and Alzheimer's disease: a new look.
2006 Nov
Ototoxic effect of Burow solution applied to the guinea pig middle ear.
2007 Aug
Reversible myocardial injury associated with aluminum phosphide poisoning.
2007 Sep
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.
2007 Sep-Oct
Aluminum phosphide fatalities at mild exertion in asymptomatic children: a clue to understand the variations of the autopsy findings.
2009 Aug
Altered glucose homeostasis in response to aluminium phosphide induced cellular oxygen deficit in rat.
2010 Jul
Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome.
2011 Mar
Effect of acute aluminum phosphide exposure on rats: a biochemical and histological correlation.
2012 Nov 23
Patents

Sample Use Guides

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use
Route of Administration: Topical
Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.
Name Type Language
POTASSIUM ALUM ANHYDROUS
Common Name English
BURNT ALUM
Common Name English
ALUM, POTASSIUM [HSDB]
Common Name English
BURNT ALUM (ANHYDROUS)
Common Name English
INS-522
Code English
POTASSIUM-ALUM-
Common Name English
E-522
Code English
ALUMINUM POTASSIUM SULPHATE ANHYDROUS
Common Name English
ALUMINIUM POTASSIUM SULFATE ANHYDROUS
Common Name English
POTASSIUM-ALUM
Common Name English
ALUMINUM POTASSIUM SULFATE ANHYDROUS
Common Name English
ALUMINUM POTASSIUM SULFATE [MI]
Common Name English
ALUMINUM POTASSIUM SULPHATE
Systematic Name English
ALUMINIUM POTASSIUM-SULFATE DODECAHYDRATE
Systematic Name English
ALUMINUM POTASSIUM SULPHATE (1:1:2)
Systematic Name English
INS NO.522
Code English
ALUMINUM POTASSIUM SULFATE [FCC]
Common Name English
SULFURIC ACID, ALUMINIUM POTASSIUM SALT (2:1:1)
Common Name English
Aluminium potassium sulfate [WHO-DD]
Common Name English
ALUMINUM POTASSIUM SULFATE [VANDF]
Common Name English
ALUMINUM POTASSIUM SULFATE, ANHYDROUS
Common Name English
SULFURIC ACID, ALUMINUM POTASSIUM SALT (2:1:1)
Common Name English
ALUMINUM POTASSIUM SULFATE
FCC   MI   VANDF  
Systematic Name English
ALUM, POTASSIUM ANHYDROUS
Common Name English
ALUMINIUM POTASSIUM SULFATE
WHO-DD  
Systematic Name English
ALUMINUM POTASSIUM SULFATE (1:1:2)
Systematic Name English
ALUMINIUM POTASSIUM SULFATE (1:1:2)
Systematic Name English
POTASH-ALUM
Common Name English
Classification Tree Code System Code
JECFA EVALUATION INS-522
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
EPA PESTICIDE CODE 128899
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
Code System Code Type Description
MERCK INDEX
m1624
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY Merck Index
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
CONCEPT Industrial Aid
CHEBI
86463
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
CAS
10043-67-1
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
EPA CompTox
DTXSID9039234
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
RXCUI
54989
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
ALTERNATIVE
HSDB
2685
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
FDA UNII
09OXB01F3O
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
SMS_ID
100000077680
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
NCI_THESAURUS
C82278
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
RXCUI
1363564
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
PUBCHEM
24856
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
EVMPD
SUB12834MIG
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
DRUG BANK
DB09087
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY
ECHA (EC/EINECS)
233-141-3
Created by admin on Fri Dec 15 16:17:31 GMT 2023 , Edited by admin on Fri Dec 15 16:17:31 GMT 2023
PRIMARY