POTASSIUM ALUM

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	Al.K.2O4S.12H2O
Molecular Weight	474.388
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O

InChI

InChIKey=GNHOJBNSNUXZQA-UHFFFAOYSA-J

InChI=1S/Al.K.2H2O4S.12H2O/c;;2*1-5(2,3)4;;;;;;;;;;;;/h;;2*(H2,1,2,3,4);12*1H2/q+3;+1;;;;;;;;;;;;;;/p-4

HIDE SMILES / InChI

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Al
Molecular Weight	26.9815
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.domeboro.com/about-domeboro/
Curator's Comment: Description was created based on several sources, including https://www.google.com/patents/US2824042 | https://www.ncbi.nlm.nih.gov/pubmed/22718290 | https://www.ncbi.nlm.nih.gov/pubmed/15516810 | https://www.ncbi.nlm.nih.gov/pubmed/10211213 | https://www.drugs.com/monograph/aluminum-acetate.html

Burow invented an astringent antiseptic solution of aluminium acetate in water to relieve the itching and inflammation of minor skin irritations. At present the oflicial U. S. P. procedure to made Burow's solution involves the reaction of aluminum sulfate, calcium carbonate and acetic acid to form aluminum sub-acetate, also termed basic aluminum acetate. The solution is available as an over-the-counter drug for topical administration, with brand names including Domeboro. Burow's solution has been shown to be effective against chronic suppurative otitis media and otitis externa. It is active against bacteria resulting in damage to the cell wall.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cell membrane 37 Target ID: CHEMBL2364031 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22718290 \| https://www.ncbi.nlm.nih.gov/pubmed/10211213	Interacts 314
vasoconstriction 28 Target ID: GO:0042310 Sources: https://www.drugs.com/monograph/aluminum-acetate.html	Activator 1404

Conditions

Condition	Modality	Targets	Highest Phase	Product
Itching 50 Sources: http://www.domeboro.com/about-domeboro/ https://www.drugs.com/monograph/aluminum-acetate.html	Primary		Approved 8307	DOMEBORO Approved Use Temporarily relieves minor skin irritations due to: – Poison ivy \| – Poison oak – Poison sumac \| – Insect bites – Athlete’s foot \| – Rashes caused by soaps, detergents, cosmetics, or jewelry
Otitis 36 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15516810 https://www.ncbi.nlm.nih.gov/pubmed/14724484 https://www.drugs.com/monograph/aluminum-acetate.html	Curative		Approved 8307	DOMEBORO Approved Use This medication is used to treat an outer ear infection (external otitis). This product contains acetic acid/aluminum acetate, a combination that stops the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear. Wetness in the ear canal can help bacteria and fungus to grow. This medication also causes drying of the ear canal, helping to cure the infection.

PubMed

Title	Date	PubMed
The ineffectiveness of aluminum subacetate in rheumatoid arthritis.	1948 Apr 8	18911341
Plasma renin activity in shock due to aluminium phosphide poisoning.	1990 Jun	2200784
The antibacterial activity of acetic acid and Burow's solution as topical otological preparations.	1998 Oct	10211213
Effect of aluminum phosphide on blood glucose level.	1999 Feb	9949483
Aluminum as a toxicant.	2002 Aug	15068131
The role of metals in neurodegenerative processes: aluminum, manganese, and zinc.	2003 Nov 15	14596888
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].	2004 Nov	15516810
Aluminum: new recognition of an old problem.	2005 Dec	16198633
Some aspects of astroglial functions and aluminum implications for neurodegeneration.	2006 Aug 30	16529821
Aluminum and other metals in Alzheimer's disease: a review of potential therapy with chelating agents.	2006 Nov	17119296
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.	2006 Nov	17119290
Ototoxic effect of Burow solution applied to the guinea pig middle ear.	2007 Aug	17450104
Neurological adverse events of immunization: experience with an aluminum adjuvanted meningococcal B outer membrane vesicle vaccine.	2007 Oct	17931164
Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation.	2007 Oct	17931150
Ablative laser resurfacing: high-energy pulsed carbon dioxide and erbium:yttrium-aluminum-garnet.	2007 Sep-Oct	17870524
Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor.	2008 Jul	18829736
Gene expression profile of mouse fibroblasts exposed to a biodegradable iron alloy for stents.	2013 Nov	23499988
1H NMR spectroscopic analysis detects metabolic disturbances in rat urine on acute exposure to heavy metal tungsten alloy based metals salt.	2014 Mar 25	24412238
Molecular basis of carcinogenicity of tungsten alloy particles.	2015 Mar 15	25620057

Patents

Sample Use Guides

In Vivo Use Guide

DOMEBORO® SOOTHING SOAK – dissolve 1 to 3 packets in a pint (16 oz) of cool or warm water – stir until fully dissolved; do not strain or filter. The resulting mixture contains 0.16% (1 packet), 0.32% (2 packets), or 0.48% (3 packets) aluminum acetate and is ready for use For use as a soak: – soak affected area for 15 to 30 minutes as needed, or as directed by a doctor – repeat 3 times a day or as directed by a doctor – discard solution after each use. For use as a compress or wet dressing: – soak a clean, soft cloth in the solution. – apply cloth loosely to affected area for 15 to 30 minutes – repeat as needed or as directed by a doctor – discard solution after each use

Route of Administration: Topical

In Vitro Use Guide

Burow's solution (13% aluminum subacetate) is active against S. aureus and P. aeruginosa, resulting in damage to the cell wall.

Substance Class	Chemical Created by `admin` on `Fri Dec 16 21:25:26 UTC 2022` Edited by `admin` on `Fri Dec 16 21:25:26 UTC 2022`
Record UNII	1L24V9R23S
Record Status	`Validated (UNII)`
Record Version

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Related Record	Type

Name

Type

Language

POTASSIUM ALUM

Official Name

English

ALUM,POTASSIUM

Common Name

English

KALINITE

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English

BAIFAN

Common Name

English

Alum [WHO-DD]

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ALUMINUM POTASSIUM SULPHATE (1:1:2) DODECAHYDRATE

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ALUMINIUM POTASSIUM SULFATE (1:1:2) DODECAHYDRATE

Common Name

English

POTASSIUM ALUM [II]

Common Name

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SULFURIC ACID, ALUMINUM POTASSIUM SALT (2:1:1), DODECAHYDRATE

Common Name

English

POTASSIUM ALUM [INCI]

Common Name

English

ALUM, POTASSIUM [USP IMPURITY]

Common Name

English

Aluminum potassium sulfate (1:1:2) dodecahydrate

Common Name

English

ALUM	Locators: WHO-DD Sources:

Common Name

English

ALUMINUM POTASSIUM SULFATE HYDRATE [JAN]

Common Name

English

POTASSIUM ALUM [VANDF]

Common Name

English

ALUMINUM POTASSIUM SULFATE DODECAHYDRATE [MI]

Common Name

English

SULFURIC ACID, ALUMINIUM POTASSIUM SALT (2:1:1), DODECAHYDRATE

Common Name

English

ALUMINIUM POTASSIUM SULFATE DODECAHYDRATE

Systematic Name

English

ALUM,POTASSIUM [VANDF]

Common Name

English

ALUMINUM POTASSIUM SULFATE HYDRATE

Systematic Name

English

ALUMEN [CHP]

Common Name

English

POTASSIUM ALUM DODECAHYDRATE [USP MONOGRAPH]

Common Name

English

ALUM, POTASSIUM

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2554