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Details

Stereochemistry ACHIRAL
Molecular Formula C14H20N2O.ClH
Molecular Weight 268.782
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TYMAZOLINE HYDROCHLORIDE

SMILES

Cl.CC(C)C1=CC=C(C)C=C1OCC2=NCCN2

InChI

InChIKey=DKIDQLUKAZZLAR-UHFFFAOYSA-N
InChI=1S/C14H20N2O.ClH/c1-10(2)12-5-4-11(3)8-13(12)17-9-14-15-6-7-16-14;/h4-5,8,10H,6-7,9H2,1-3H3,(H,15,16);1H

HIDE SMILES / InChI

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21796997 | https://www.ncbi.nlm.nih.gov/pubmed/2481638 | https://www.drugs.com/international/tymazoline.html

Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis and nasal obstruction. Tymazoline is a drug with antihistaminic and sympathomimetic properties. It locally reduces swelling, inflammation and mucosal secretions of the nasal passages. Thymazen causes vasoconstriction of the nasal mucosa, reducing congestion and thus the swelling of the mucosa. Also reduces the secretions from the nose. Thymazen acts on alpha-adrenergic receptors, which reduces local inflammation of the nasal mucosa especially if their cause is an allergy.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL231
Sources: Acta Poloniae Pharmaceutica (1960), 17, 349-53.
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Thymazen

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effects of different mechanical treatments on nasal resistance assessed by rhinometry.
1998-07
A new ex vivo method for the study of nasal drops on ciliary function.
1989
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
THYMAZEN
Preferred Name English
TYMAZOLINE HYDROCHLORIDE
WHO-DD  
Common Name English
Tymazoline hydrochloride [WHO-DD]
Common Name English
1H-IMIDAZOLE, 4,5-DIHYDRO-2-((5-METHYL-2-(1-METHYLETHYL)PHENOXY)METHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
2-IMIDAZOLINE, 2-((THYMYLOXY)METHYL)-, MONOHYDROCHLORIDE
Common Name English
1H-IMIDAZOLE, 4,5-DIHYDRO-2-((5-METHYL-2-(1-METHYLETHYL)PHENOXY)METHYL)-, MONOHYDROCHLORIDE
Common Name English
Code System Code Type Description
FDA UNII
06223H196A
Created by admin on Mon Mar 31 22:00:52 GMT 2025 , Edited by admin on Mon Mar 31 22:00:52 GMT 2025
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PUBCHEM
34153
Created by admin on Mon Mar 31 22:00:52 GMT 2025 , Edited by admin on Mon Mar 31 22:00:52 GMT 2025
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ECHA (EC/EINECS)
248-854-5
Created by admin on Mon Mar 31 22:00:52 GMT 2025 , Edited by admin on Mon Mar 31 22:00:52 GMT 2025
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CAS
28120-03-8
Created by admin on Mon Mar 31 22:00:52 GMT 2025 , Edited by admin on Mon Mar 31 22:00:52 GMT 2025
PRIMARY
EVMPD
SUB15641MIG
Created by admin on Mon Mar 31 22:00:52 GMT 2025 , Edited by admin on Mon Mar 31 22:00:52 GMT 2025
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SMS_ID
100000077288
Created by admin on Mon Mar 31 22:00:52 GMT 2025 , Edited by admin on Mon Mar 31 22:00:52 GMT 2025
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