U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H20N2O
Molecular Weight 232.3214
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TYMAZOLINE

SMILES

CC(C)C1=C(OCC2=NCCN2)C=C(C)C=C1

InChI

InChIKey=QRORCRWSRPKEHR-UHFFFAOYSA-N
InChI=1S/C14H20N2O/c1-10(2)12-5-4-11(3)8-13(12)17-9-14-15-6-7-16-14/h4-5,8,10H,6-7,9H2,1-3H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula C14H20N2O
Molecular Weight 232.3214
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21796997 | https://www.ncbi.nlm.nih.gov/pubmed/2481638 | https://www.drugs.com/international/tymazoline.html

Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis and nasal obstruction. Tymazoline is a drug with antihistaminic and sympathomimetic properties. It locally reduces swelling, inflammation and mucosal secretions of the nasal passages. Thymazen causes vasoconstriction of the nasal mucosa, reducing congestion and thus the swelling of the mucosa. Also reduces the secretions from the nose. Thymazen acts on alpha-adrenergic receptors, which reduces local inflammation of the nasal mucosa especially if their cause is an allergy.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: CHEMBL231
Sources: Acta Poloniae Pharmaceutica (1960), 17, 349-53.
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Thymazen

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
A new ex vivo method for the study of nasal drops on ciliary function.
1989
Effects of different mechanical treatments on nasal resistance assessed by rhinometry.
1998 Jul
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:30:49 GMT 2023
Edited
by admin
on Fri Dec 15 15:30:49 GMT 2023
Record UNII
U993RH5585
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TYMAZOLINE
MI   WHO-DD  
Common Name English
Tymazoline [WHO-DD]
Common Name English
2-(2-ISOPROPYL-5-METHYLPHENOXYMETHYL)-2-IMIDAZOLINE
Systematic Name English
TYMAZOLINE [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QR01AA13
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
NCI_THESAURUS C29713
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
WHO-ATC R01AA13
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID40178939
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
CAS
24243-97-8
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
SMS_ID
100000077306
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
WIKIPEDIA
Tymazoline
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
FDA UNII
U993RH5585
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
MERCK INDEX
m11285
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB08803
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
EVMPD
SUB15640MIG
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106467
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
NCI_THESAURUS
C95309
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
DRUG CENTRAL
3445
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
PUBCHEM
34154
Created by admin on Fri Dec 15 15:30:49 GMT 2023 , Edited by admin on Fri Dec 15 15:30:49 GMT 2023
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT