TYMAZOLINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H20N2O.ClH
Molecular Weight	268.782
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)C1=C(OCC2=NCCN2)C=C(C)C=C1

InChI

InChIKey=DKIDQLUKAZZLAR-UHFFFAOYSA-N

InChI=1S/C14H20N2O.ClH/c1-10(2)12-5-4-11(3)8-13(12)17-9-14-15-6-7-16-14;/h4-5,8,10H,6-7,9H2,1-3H3,(H,15,16);1H

HIDE SMILES / InChI

Molecular Formula	C14H20N2O
Molecular Weight	232.3214
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugbank.ca/drugs/DB08803
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/21796997 | https://www.ncbi.nlm.nih.gov/pubmed/2481638 | https://www.drugs.com/international/tymazoline.html

Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis and nasal obstruction. Tymazoline is a drug with antihistaminic and sympathomimetic properties. It locally reduces swelling, inflammation and mucosal secretions of the nasal passages. Thymazen causes vasoconstriction of the nasal mucosa, reducing congestion and thus the swelling of the mucosa. Also reduces the secretions from the nose. Thymazen acts on alpha-adrenergic receptors, which reduces local inflammation of the nasal mucosa especially if their cause is an allergy.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: Acta Poloniae Pharmaceutica (1960), 17, 349-53.	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rhinitis 20 Sources: https://www.drugbank.ca/drugs/DB08803	Primary		Approved 8429	Thymazen Approved Use Unknown

PubMed

Title	Date	PubMed
Effects of different mechanical treatments on nasal resistance assessed by rhinometry.	1998 Jul	9674465

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:20:15 GMT 2023` Edited by `admin` on `Sat Dec 16 08:20:15 GMT 2023`
Record UNII	06223H196A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TYMAZOLINE HYDROCHLORIDE

Common Name

English

Tymazoline hydrochloride [WHO-DD]

Common Name

English

1H-IMIDAZOLE, 4,5-DIHYDRO-2-((5-METHYL-2-(1-METHYLETHYL)PHENOXY)METHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

2-IMIDAZOLINE, 2-((THYMYLOXY)METHYL)-, MONOHYDROCHLORIDE

Common Name

English

1H-IMIDAZOLE, 4,5-DIHYDRO-2-((5-METHYL-2-(1-METHYLETHYL)PHENOXY)METHYL)-, MONOHYDROCHLORIDE

Common Name

English

THYMAZEN

Brand Name

English

Code System Code Type Description

FDA UNII

06223H196A