Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H14NO3.Cl |
| Molecular Weight | 255.697 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].COC1=C2OCOC2=CC3=C1C=[N+](C)CC3
InChI
InChIKey=BWQAGVANIBSWBW-UHFFFAOYSA-M
InChI=1S/C12H14NO3.ClH/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13;/h5-6H,3-4,7H2,1-2H3;1H/q+1;/p-1
Cotarninium is a uterotonic agent. It increases the tone of smooth muscles of internal organs, particularly the uterus. Indicated for the treatment of uterus subinvolution (after childbirth and abortion), dysfunctional uterine bleeding and bleeding due to fibroids and inflammatory processes. Side effects are nausea, allergic reactions. Contraindications are pregnancy and hypersensitivity to the agent.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | STYPTICIN Approved UseIndicated for the treatment of delayed uterine involution, uterine bleeding after childbirth, abortion and others. Launch Date1964 |
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| Primary | STYPTICIN Approved UseIndicated for the treatment of delayed uterine involution, uterine bleeding after childbirth, abortion and others. Launch Date1964 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [The detection of abortion agents in biological material]. | 1992 Jan-Mar |
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| Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses. | 2000 Jul |
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| Validated stability-indicating TLC method for the determination of noscapine. | 2009 Jul |
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| Metabolic pathway profiling of the derivative of important herbal component noscapine. | 2016 Feb |
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| Metal-Free Activation of a C(sp)-H Bond of Aryl Acetylenes. | 2016 Oct 10 |
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| A new approach to alkaloid-like systems: synthesis and crystal structure of 1-(2-acetyl-11-meth-oxy-5,6-di-hydro-[1,3]dioxolo[4,5-g]pyrrolo-[2,1-a]isoquinolin-1-yl)propan-2-one. | 2017 Nov 1 |
Patents
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NCI_THESAURUS |
C221
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ACTIVE MOIETY
SUBSTANCE RECORD
