COTARNINE CHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14NO3.Cl
Molecular Weight	255.697
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].COC1=C2OCOC2=CC3=C1C=[N+](C)CC3

InChI

InChIKey=BWQAGVANIBSWBW-UHFFFAOYSA-M

InChI=1S/C12H14NO3.ClH/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13;/h5-6H,3-4,7H2,1-2H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	C12H14NO3
Molecular Weight	220.2445
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1007/978-3-642-90745-6_167 | http://vse-tabletki.ru/kotarnina-khlorid-cotarnini-chloridum | https://www.webapteka.ru/drugbase/name3341.html

Cotarninium is a uterotonic agent. It increases the tone of smooth muscles of internal organs, particularly the uterus. Indicated for the treatment of uterus subinvolution (after childbirth and abortion), dysfunctional uterine bleeding and bleeding due to fibroids and inflammatory processes. Side effects are nausea, allergic reactions. Contraindications are pregnancy and hypersensitivity to the agent.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Uterus subinvolution 2 Sources: https://www.smed.ru/guides/41004	Primary		Approved 8429	STYPTICIN Approved Use Indicated for the treatment of delayed uterine involution, uterine bleeding after childbirth, abortion and others. Launch Date 1964
Uterine hemorrhage 5 Sources: https://www.piluli.kharkov.ua/drugs/drug/1243/	Primary		Approved 8429	STYPTICIN Approved Use Indicated for the treatment of delayed uterine involution, uterine bleeding after childbirth, abortion and others. Launch Date 1964

PubMed

Title	Date	PubMed
[The detection of abortion agents in biological material].	1992 Jan-Mar	1589888
Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses.	2000 Jul	10941904
Validated stability-indicating TLC method for the determination of noscapine.	2009 Jul	20355211
Metabolic pathway profiling of the derivative of important herbal component noscapine.	2016 Feb	25336326
Metal-Free Activation of a C(sp)-H Bond of Aryl Acetylenes.	2016 Oct 10	27504988
A new approach to alkaloid-like systems: synthesis and crystal structure of 1-(2-acetyl-11-meth-oxy-5,6-di-hydro-[1,3]dioxolo[4,5-g]pyrrolo-[2,1-a]isoquinolin-1-yl)propan-2-one.	2017 Nov 1	29152361

Patents

Sample Use Guides

In Vivo Use Guide

Subcutaneous: 1 ml of 2-5% solution Topical: Locally 1-2% solution Oral: 50-100 mg 3 times a day

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:13:42 GMT 2023` Edited by `admin` on `Fri Dec 15 17:13:42 GMT 2023`
Record UNII	03F6B8N3QN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COTARNINE CHLORIDE

Common Name

English

COTARNIN CHLORIDE

Common Name

English

NSC-24824

Code

English

COTARNINIUM CHLORIDE

Common Name

English

COTARNINE CHLORIDE [MART.]

Common Name

English

1,3-DIOXOLO(4,5-G)ISOQUINOLINIUM, 7,8-DIHYDRO-4-METHOXY-6-METHYL-, CHLORIDE (1:1)

Systematic Name

English

STYPTICIN

Brand Name

English

Cotarnin chloride [WHO-DD]

Common Name

English

COTARNINE CHLORIDE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C221