Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H16NO5PS2 |
Molecular Weight | 325.342 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COP(=S)(OC)OC1=CC=C(C=C1)S(=O)(=O)N(C)C
InChI
InChIKey=JISACBWYRJHSMG-UHFFFAOYSA-N
InChI=1S/C10H16NO5PS2/c1-11(2)19(12,13)10-7-5-9(6-8-10)16-17(18,14-3)15-4/h5-8H,1-4H3
Famphur is an insecticide and antihelmenthic. Famphur is approved in cattle as a pour-on (NADA 34-697; 21 CFR 524.900) and as
medicated feed (NADA 34-266; 21 CFR 558.254). It is a component of the FDA-approved TRAMISOL X-TRA Combination Paste, used for the treatment of cattle infected with the following parasites: Stomach worms (Haemonchus, Trichostrongylus, Ostertagia), intestinal worms (Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Oesophagostomum), lungworms (Dictyocaulus), cattle grubs (Hypoderma), biting lice (Bovicola), and sucking lice (Linognathus, Solenoptes). Famphur is a cholinesterase-inhibiting drug.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL4768 |
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Target ID: CHEMBL612397 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3693663 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | TRAMISOL X-TRA Approved UseFor treatment of cattle infected with the following parasites:
1) STOMACH WORMS: Haemonchus, Trichostrongylus, Ostertagia
2) INTESTINAL WORMS: Trichostrongylus, Cooperia, Nematodirus,
Bunostomum, Oesophagostomum
3) LUNGWORMS: Dictyocaulus
4) BITING LICE: Bovicola
5) SUCKING LICE: Linognathus, Solenoptes
It is not effective against lice eggs. Launch Date1968 |
PubMed
Title | Date | PubMed |
---|---|---|
Avian mortality events in the United States caused by anticholinesterase pesticides: a retrospective summary of National Wildlife Health Center records from 1980 to 2000. | 2004 May |
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Prediction for the mixture toxicity of six organophosphorus pesticides to the luminescent bacterium Q67. | 2008 Nov |
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Longitudinal trends in organophosphate incidents reported to the National Pesticide Information Center, 1995-2007. | 2009 Apr 20 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.pwrc.usgs.gov/eisler/CHR_27_Famphur.pdf
Curator's Comment: Famphur could also be used topically: calves were treated with famphur at three dosage levels 20.25 mg/kg, 40.5 mg/kg and 60.75 mg/kg.
https://www.ncbi.nlm.nih.gov/pubmed/7284948
TRAMISOL X-TRA Combination Paste contains levamisole resinate (50%) and
famphur as active ingredients packed in a polyethylene cartridge-type container.
TRAMISOL X-TRA is formulated to provide 8 mg/kg (3.6 mg/lb) of body weight of
levamisole HCl equivalent activity and 30 mg/kg (13.6 mg/lb) of body weight of
famphur activity which has been demonstrated to be the optimum dose level for
effective performance the product's anthelmintic and ectoparasitic label claims.
TRAMISOL X-TRA is administered to cattle in individual oral doses using the
compatible GelGun ®oral dispensing device. The product has been designed so
that each distinct depression of the Gel Gun trigger or "click" delivers a 0.18 g
levamisole and 0.68 g famphur activity which is the appropriate dose for each 50
lb body weight. In practice TRAMISOL X-TRA is administered by setting the Gel
Gun weight selector for the approximate weight of the animal to be treated,
directing the nozzle of the cartridge through the interdental space and squeezing
the trigger two times directing the paste over the tongue into the animal's throat.
Route of Administration:
Other
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Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
59901
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CFR |
21 CFR 558.254
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CFR |
21 CFR 520.1242G
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CFR |
21 CFR 556.273
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NCI_THESAURUS |
C737
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CFR |
21 CFR 524.900
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m1150
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38677
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famphur
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SUBSTANCE RECORD