HEXAMIDINE DIISETHIONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H26N4O2.2C2H6O4S
Molecular Weight	606.709
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)C1=CC=C(OCCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1

InChI

InChIKey=NBVZMBLJRHUOJR-UHFFFAOYSA-N

InChI=1S/C20H26N4O2.2C2H6O4S/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24;2*3-1-2-7(4,5)6/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24);2*3H,1-2H2,(H,4,5,6)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28129440 | https://www.ncbi.nlm.nih.gov/pubmed/26235920

Hexamidine diisethionate has been used in the personal care industry and in a number of over-the-counter (OTC) drug products as an antimicrobial agent. It was shown, that hexamidine diisethionate plays a beneficial role in skin homoeostasis.

Approval Year

PubMed

Title	Date	PubMed
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.	1990 Apr	2319567
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.	2001 Apr 26	11311057
Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.	2007	18273451
Visual outcome and rehabilitation in a case of bilateral acanthamoeba sclerokeratitis.	2007 Oct	17893557
In vitro activity of para-guanidinoethylcalix[4]arene against susceptible and antibiotic-resistant Gram-negative and Gram-positive bacteria.	2007 Sep	17626025
A new Sephadex-based method for removing microbicidal and cytotoxic residues when testing antiseptics against viruses: Experiments with a human coronavirus as a model.	2009 Aug	19490977
p-Guanidinoethyl calixarene and parent phenol derivatives exhibiting antibacterial activities. Synthesis and biological evaluation.	2009 Aug 1	19596201

Patents

Name

Type

Language

HEXAMIDINE DIISETHIONATE

Official Name

English

Hexamidine isetionate [WHO-DD]

Common Name

English

HEXAMIDINE ISETIONATE

Common Name

English

4,4'-(HEXAMETHYLENEDIOXY)DIBENZAMIDINE ISETHIONATE

Systematic Name

English

HEXAMIDINE DIISETIONATE [EP MONOGRAPH]

Common Name

English

HEXAMIDINE DIISETIONATE

Common Name

English

HEXAMIDINE ISETIONATE [MART.]

Common Name

English

HEXAMIDINE DIISETHIONATE [INCI]

Common Name

English

HEXAMIDINE ISETHIONATE

Common Name

English

HEXOMEDIN

Brand Name

English

HEXAMIDINE ISETHIONATE [MI]

Common Name

English

RF-2535

Code

English

HEXAMIDINE DIISETIONATE [EP IMPURITY]

Common Name

English

NSC-115848

Code

English

4,4'-(HEXAMETHYLENEDIOXY)DIBENZAMIDINE BIS(2-HYDROXYETHANESULPHONATE)

Systematic Name

English

Code System Code Type Description

MERCK INDEX

m6000