HEXAMIDINE DIISETHIONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H26N4O2.2C2H6O4S
Molecular Weight	606.709
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)C1=CC=C(OCCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1

InChI

InChIKey=NBVZMBLJRHUOJR-UHFFFAOYSA-N

InChI=1S/C20H26N4O2.2C2H6O4S/c21-19(22)15-5-9-17(10-6-15)25-13-3-1-2-4-14-26-18-11-7-16(8-12-18)20(23)24;2*3-1-2-7(4,5)6/h5-12H,1-4,13-14H2,(H3,21,22)(H3,23,24);2*3H,1-2H2,(H,4,5,6)

HIDE SMILES / InChI

Molecular Formula	C2H6O4S
Molecular Weight	126.132
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H26N4O2
Molecular Weight	354.446
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28129440 | https://www.ncbi.nlm.nih.gov/pubmed/26235920

Hexamidine diisethionate has been used in the personal care industry and in a number of over-the-counter (OTC) drug products as an antimicrobial agent. It was shown, that hexamidine diisethionate plays a beneficial role in skin homoeostasis.

Approval Year

PubMed

Title	Date	PubMed
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.	1990 Apr	2319567
1,5-Bis(4-amidinophenoxy)pentane (pentamidine) is a potent inhibitor of [3H]idazoxan binding to imidazoline I2 binding sites.	1998 Jul 17	9721046
Bilateral Acanthamoeba keratitis with late recurrence of the infection in a corneal graft: a case report.	2003 Apr	12747654
Persistently culture positive acanthamoeba keratitis: in vivo resistance and in vitro sensitivity.	2003 Aug	12917179
Systemic allergy to topical hexamidine.	2006 Aug 7	16893365
A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.	2006 Jun	16783150
[Clinical tolerance of cutaneous antiseptics in 3,403 patients in France].	2006 Oct	17072189
[Towards new antibacterial drugs. Interest of para-guanidinoethylcalix[4]arene].	2006 Oct-Nov	17023121
[Acanthamoeba keratitis: about the first two Tunisian cases].	2007 Feb	17402694
In vitro activity of para-guanidinoethylcalix[4]arene against susceptible and antibiotic-resistant Gram-negative and Gram-positive bacteria.	2007 Sep	17626025
Antistaphylococcal activities of CG400549, a new bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor.	2007 Sep	17606482
A new Sephadex-based method for removing microbicidal and cytotoxic residues when testing antiseptics against viruses: Experiments with a human coronavirus as a model.	2009 Aug	19490977
p-Guanidinoethyl calixarene and parent phenol derivatives exhibiting antibacterial activities. Synthesis and biological evaluation.	2009 Aug 1	19596201
Understanding metabolic pathways for skin anti-aging.	2009 Jul	19623777
Painless Acanthamoeba keratitis in a soft contact lens wearer--case report.	2009 Sep	19860131
[Infectious keratitis and cosmetic lenses: a five-case retrospective study].	2010 Apr	20223558
[Effect of psychotropic drugs on activity of anticonvulsants in maximal electroshock test].	2010 Aug	20919549
Action potential-enhanced ATP release from taste cells through hemichannels.	2010 Aug	20519578
Antiseptic properties of two calix[4]arenes derivatives on the human coronavirus 229E.	2010 Dec	20854844
[Acanthamoeba keratitis. Report of 3 cases diagnosed in central Tunisia].	2010 Feb	20415171

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:49:15 GMT 2023` Edited by `admin` on `Fri Dec 15 17:49:15 GMT 2023`
Record UNII	023XA5Z50L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

HEXAMIDINE DIISETHIONATE

Official Name

English

Hexamidine isetionate [WHO-DD]

Common Name

English

HEXAMIDINE ISETIONATE

Common Name

English

4,4'-(HEXAMETHYLENEDIOXY)DIBENZAMIDINE ISETHIONATE

Systematic Name

English

HEXAMIDINE DIISETIONATE [EP MONOGRAPH]

Common Name

English

HEXAMIDINE DIISETIONATE

Common Name

English

HEXAMIDINE ISETIONATE [MART.]

Common Name

English

HEXAMIDINE DIISETHIONATE [INCI]

Common Name

English

HEXAMIDINE ISETHIONATE

Common Name

English

HEXOMEDIN

Brand Name

English

HEXAMIDINE ISETHIONATE [MI]

Common Name

English

RF-2535

Code

English

HEXAMIDINE DIISETIONATE [EP IMPURITY]

Common Name

English

NSC-115848

Code

English

4,4'-(HEXAMETHYLENEDIOXY)DIBENZAMIDINE BIS(2-HYDROXYETHANESULPHONATE)

Systematic Name

English

Code System Code Type Description

MERCK INDEX

m6000