U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1 - 10 of 12 results

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Possibly Marketed Outside US
Source:
NCT02107144: Phase 4 Interventional Completed Coronary Artery Disease
(2014)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Trimetazidine is a medicine, which is used for the treatment of angina pectoris. The drug mechanism of action is explained by its ability to selectively inhibit long-chain 3-ketoacyl coenzyme A thiolase, an enzyme responsible for mitochondrial beta-oxidation of long chain fatty acids. Trimetazidine also increases pyruvate dehydrogenase activity, binds to the mitochondrial membrane, directly inhibits cardiac fibrosis and improves mechanical resistance of the sarcolemma.
mixture
Status:
US Approved Rx (2013)
Source:
BLA125416
(2013)
Source URL:
First approved in 1958
Source:
BLA101140
Source URL:

Class:
MIXTURE

Showing 1 - 10 of 12 results