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Search results for benazepril in Related Substance Name (approximate match)
Status:
US Approved Rx
(2004)
Source:
ANDA076631
(2004)
Source URL:
First approved in 1991
Source:
NDA019851
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
BENAZEPRIL, (±)- is an impurity referred to as Related Compound B, which is a diastereomer of benazepril, an ACE inhibitor, under the brand name Lotensin used primarily in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing the renal and retinal complications of diabetes. BENAZEPRIL, (±)- is used as USP Reference Standard.
Benazepril Related Compound A, it is an Impurity. Benazepril is a prodrug which is metabolized by the liver into its active form benazeprilat via cleavage of the drug's ester group. Benazepril and Benazeprilat inhibit angiotensin-converting enzyme (ACE) in human subjects and animals. Benazeprilat has much greater ACE inhibitory activity than does Benazepril. It is indicated for the treatment of hypertension.
Status:
US Approved Rx
(2013)
First approved in 1958
Class:
MIXTURE
![Structure of [(3S)-3-[[(1S)-3-cyclohexyl-1-(ethoxycarbonyl)propyl]amino]-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid](/img/ed9db1ee-1953-454a-aa40-304dbd042c8e.svg?size=200&context=njatrifmqx)
