U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Methyldopate hydrochloride [levo-3-(3,4-dihydroxyphenyl)-2-methylalanine, ethyl ester hydrochloride] is the ethyl ester of methyldopa, supplied as the hydrochloride salt with a molecular weight of 275.73. Methyldopate hydrochloride is more soluble and stable in solution than methyldopa and is the preferred form for intravenous use. Methyldopate hydrochloride is an alpha adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
Status:
US Previously Marketed
Source:
NOV PONT W/NEOCOBEFRIN LEVONORDEFRIN by COOKE-WAITE
(1961)
Source URL:
*!
First approved in 1952
Source:
RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRIN by EASTMAN KODAK
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It is administered in a pre-mixed solution with local anesthetics, such as mepivacaine or procaine.
Status:
US Previously Marketed
Source:
NOV PONT W/NEOCOBEFRIN LEVONORDEFRIN by COOKE-WAITE
(1961)
Source URL:
*!
First approved in 1952
Source:
RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRIN by EASTMAN KODAK
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It is administered in a pre-mixed solution with local anesthetics, such as mepivacaine or procaine.