Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H13NO4 |
Molecular Weight | 211.2145 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@](N)(CC1=CC(O)=C(O)C=C1)C(O)=O
InChI
InChIKey=CJCSPKMFHVPWAR-JTQLQIEISA-N
InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
Molecular Formula | C10H13NO4 |
Molecular Weight | 211.2145 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/13400s086lbl.pdfhttps://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f5f25053-a9f3-48b9-a412-078f5ee942fd&type=displayCurator's Comment: Description was created based on several sources, including
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/13400s086lbl.pdfhttps://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=f5f25053-a9f3-48b9-a412-078f5ee942fd&type=display
Curator's Comment: Description was created based on several sources, including
Methyldopate hydrochloride [levo-3-(3,4-dihydroxyphenyl)-2-methylalanine, ethyl ester hydrochloride] is the ethyl ester of methyldopa, supplied as the hydrochloride salt with a molecular weight of 275.73. Methyldopate hydrochloride is more soluble and stable in solution than methyldopa and is the preferred form for intravenous use. Methyldopate hydrochloride is an alpha adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
CNS Activity
Sources: https://www.drugs.com/monograph/methyldopa.htmlhttps://www.drugs.com/ppa/methyldopa-and-methyldopate-hcl.html
Curator's Comment: Methyldopa and methyldopate cross the blood-brain
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1843 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7136732 |
60.0 µM [IC50] | ||
Target ID: CHEMBL2095203 |
|||
Target ID: CHEMBL2094111 Sources: https://www.drugs.com/pro/methyldopa.html |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | ALDOMET Approved UseINDICATION AND USAGE: Hypertension. Launch Date1962 |
|||
Primary | ALDOMET Approved UseINDICATION AND USAGE: Hypertension. Launch Date1962 |
|||
Primary | ALDOMET Approved UseINDICATION AND USAGE: Hypertension. Launch Date1962 |
|||
Primary | Methyldopate hydrochloride Approved UseHypertension, when parenteral medication is indicated. The treatment of hypertensive crises may be initiated with Methyldopate HCl Injection. Launch Date1995 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
771.3 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21125810 |
250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered: |
METHYLDOPA plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
4.54 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7047042 |
100 mg single, intravenous dose: 100 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
METHYLDOPA plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
5352.9 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21125810 |
250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered: |
METHYLDOPA plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
1.28 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7047042 |
100 mg single, intravenous dose: 100 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
METHYLDOPA plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
12.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/21125810 |
250 mg single, oral dose: 250 mg route of administration: Oral experiment type: SINGLE co-administered: |
METHYLDOPA plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
85% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7047042 |
100 mg single, intravenous dose: 100 mg route of administration: Intravenous experiment type: SINGLE co-administered: |
METHYLDOPA plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
2.5 g single, oral |
unknown, 19 n = 1 Health Status: unknown Age Group: 19 Sex: M Population Size: 1 Sources: |
Other AEs: Coma... |
2326 mg multiple, oral (mean) Recommended Dose: 2326 mg Route: oral Route: multiple Dose: 2326 mg Sources: |
unhealthy, 36-68 n = 30 Health Status: unhealthy Condition: hypertension Age Group: 36-68 Sex: M+F Population Size: 30 Sources: |
Disc. AE: Depression, Tiredness... AEs leading to discontinuation/dose reduction: Depression (2 patients) Sources: Tiredness (2 patients) Diarrhoea (1 patient) Rash (1 patient) Blackout (1 patient) |
250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Other AEs: Somnolence, Dry mouth... Other AEs: Somnolence (15 patients) Sources: Dry mouth (12 patients) Malaise (6 patients) Constipation (5 patients) Anorexia (5 patients) Diarrhoea (3 patients) Depression (2 patients) Weight gain (2 patients) Mental confusion (1 patient) Postural hypotension (1 patient) |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Coma | grade 1 | 2.5 g single, oral |
unknown, 19 n = 1 Health Status: unknown Age Group: 19 Sex: M Population Size: 1 Sources: |
Blackout | 1 patient Disc. AE |
2326 mg multiple, oral (mean) Recommended Dose: 2326 mg Route: oral Route: multiple Dose: 2326 mg Sources: |
unhealthy, 36-68 n = 30 Health Status: unhealthy Condition: hypertension Age Group: 36-68 Sex: M+F Population Size: 30 Sources: |
Diarrhoea | 1 patient Disc. AE |
2326 mg multiple, oral (mean) Recommended Dose: 2326 mg Route: oral Route: multiple Dose: 2326 mg Sources: |
unhealthy, 36-68 n = 30 Health Status: unhealthy Condition: hypertension Age Group: 36-68 Sex: M+F Population Size: 30 Sources: |
Rash | 1 patient Disc. AE |
2326 mg multiple, oral (mean) Recommended Dose: 2326 mg Route: oral Route: multiple Dose: 2326 mg Sources: |
unhealthy, 36-68 n = 30 Health Status: unhealthy Condition: hypertension Age Group: 36-68 Sex: M+F Population Size: 30 Sources: |
Depression | 2 patients Disc. AE |
2326 mg multiple, oral (mean) Recommended Dose: 2326 mg Route: oral Route: multiple Dose: 2326 mg Sources: |
unhealthy, 36-68 n = 30 Health Status: unhealthy Condition: hypertension Age Group: 36-68 Sex: M+F Population Size: 30 Sources: |
Tiredness | 2 patients Disc. AE |
2326 mg multiple, oral (mean) Recommended Dose: 2326 mg Route: oral Route: multiple Dose: 2326 mg Sources: |
unhealthy, 36-68 n = 30 Health Status: unhealthy Condition: hypertension Age Group: 36-68 Sex: M+F Population Size: 30 Sources: |
Mental confusion | 1 patient | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Postural hypotension | 1 patient | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Dry mouth | 12 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Somnolence | 15 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Depression | 2 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Weight gain | 2 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Diarrhoea | 3 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Anorexia | 5 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Constipation | 5 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Malaise | 6 patients | 250 mg 4 times / day multiple, oral Recommended Dose: 250 mg, 4 times / day Route: oral Route: multiple Dose: 250 mg, 4 times / day Sources: |
unhealthy n = 39 Health Status: unhealthy Condition: hypertension Sex: M+F Population Size: 39 Sources: |
Overview
CYP3A4 | CYP2C9 | CYP2D6 | hERG |
---|---|---|---|
OverviewOther
Other Inhibitor | Other Substrate | Other Inducer |
---|---|---|
Drug as victim
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://molpharm.aspetjournals.org/content/12/6/911 Page: abstract |
likely |
Tox targets
Target | Modality | Activity | Metabolite | Clinical evidence |
---|---|---|---|---|
Sources: https://www.scirp.org/pdf/JBiSE_2017112915210255.pdf Page: 10.0 |
PubMed
Title | Date | PubMed |
---|---|---|
[Use of alpha-methyldopa in the treatment of arterial hypertension]. | 1975 Aug 31 |
|
Delayed hepatotoxicity from methyldopa. | 1975 Dec |
|
Persistent parkinsonism following neuroleptanalgesia. | 1975 May |
|
Dihydroergotamine: an effective treatment for postural hypotension due to antihypertensive drugs (ganglion-blocking agents excepted). | 1976 |
|
Some side-effects of alpha-methyldopa. | 1976 Apr 10 |
|
Drug-associated acute pancreatitis: twenty-one years of spontaneous reporting in The Netherlands. | 1999 Sep |
|
Antihypertensive treatment decreased serum leptin levels in severe preeclampsia during pregnancy. | 2001 |
|
Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. | 2001 |
|
[Drug-induced hemolytic anemia]. | 2001 Aug |
|
Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy. | 2001 Aug |
|
Effect of alpha-methyldopa on pentoxyresorufin O-dealkylation in liver microsomes from rats treated with phenobarbital. | 2001 Aug 1 |
|
Drugs in pregnancy. Antihypertensives. | 2001 Dec |
|
The use of a response surface methodology on HPLC analysis of methyldopa, amiloride and hydrochlorothiazide in tablets. | 2001 Mar |
|
Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits. | 2001 Sep |
|
The immune haemolytic anaemias: a century of exciting progress in understanding. | 2001 Sep |
|
Excretion of antihypertensive medication into human breast milk: a systematic review. | 2002 |
|
Methyldopa versus no drug treatment in the management of mild pre-eclampsia. | 2002 Apr |
|
Immune-mediated drug-induced liver disease. | 2002 Aug |
|
Effects of six anti-hypertensive medications on cognitive performance. | 2002 Aug |
|
Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial. | 2002 Feb 19 |
|
Preparation of (R) and (S) alpha methyldopa from a chiral hydantoin containing the alpha phenylethyl group. | 2002 Feb-Mar |
|
Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. | 2002 Jan |
|
Rapid-eye-movement sleep in jittery infants. | 2002 Jan |
|
Hypertension/preeclampsia. | 2002 Jan-Feb |
|
The effect of methyldopa treatment on uterine, umblical and fetal middle cerebral artery blood flows in preeclamptic patients. | 2002 Jul |
|
C4 deficiency state in antiphospholipid antibody-related recurrent preeclampsia evolving into systemic lupus erythematosus. | 2002 Jul |
|
Determination of antioxidant activity of some drugs using high-pressure liquid chromatography. | 2003 |
|
Methyldopa supplement for resistant essential hypertension: a prospective randomized placebo control crossover study. | 2003 Dec |
|
Blood pressure response to out-patient drug treatment of hypertension in 1973-1993 at Korle-Bu Teaching Hospital, Accra, Ghana. | 2003 Jun |
|
Physician gender and antihypertensive prescription pattern in primary care. | 2003 Nov |
|
[Centrally-acting antihypertensive drugs]. | 2004 Mar |
|
[Hypertension in pregnancy]. | 2004 Mar |
|
Drug-induced liver injury. | 2004 Mar 1 |
|
Differential modulation by estrogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats. | 2004 Oct |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: When control has been obtained, oral therapy with tablets may be substituted for intravenous therapy, starting with the same dosage schedule used for the parenteral route. The effectiveness and anticipated responses are described in the circular for tablets.
Initial: 250 mg PO q8-12hr for 2 days, increase q2Days PRN
Maintenance: 250-1000 mg/day divided q6-12hr PO, usually no more than 3 g/day
IV (methyldopate): 250-1000 mg infusion over 30-60 minutes q6-8hr PRN; no more than 4 g/day
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27998008
Human uterine microvascular endothelial cells (UtMVEC) (PromoCell, Heidelberg, Germany) were cultured in EGM-2- MV medium (Lonza, Basel, Switzerland) until about 80% confluent. Cells from passage 4-8 were used in this study. Tissue culture plates (24-wells) were coated with undiluted Matrigel (300 μL/well; In Vitro Technologies, Noble Park, Vic., Australia) and polymerized for 30 minutes at 37°C. UtMVECs (100 000 cells/well) were seeded into each well and endothelial cell tubular networks formed within 4 hours of further incubation at 37°C. HTR-8/ SVneo cells (100 000 cells/well) were then added to each well with or without a low dose of TNF-α (0.5 ng/mL) together with methyldopa (5 μg/ mL), labetalol (0.5 μg/mL), hydralazine (10 μg/mL) or clonidine (1.0 μg/ mL) and co-cultured with the endothelial cellular networks. The control co-cultured cells had neither TNF-α nor medications added. After 24 hours of culture, the cells were retrieved from the cellular networks in Matrigel with Cell Recovery Solution (CRS) (In Vitro Technologies) for RNA extraction
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:57:41 GMT 2023
by
admin
on
Fri Dec 15 15:57:41 GMT 2023
|
Record UNII |
M4R0H12F6M
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-ATC |
C02AB01
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
||
|
NDF-RT |
N0000175554
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
||
|
WHO-ATC |
C02LB01
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
||
|
NDF-RT |
N0000009918
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
||
|
WHO-ATC |
C02AB
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
38853
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
209-089-2
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
1545996
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | RxNorm | ||
|
SUB08867MIG
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
1110
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
M4R0H12F6M
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
218
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
DTXSID5023295
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
C175729
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
SUB26433
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
m7397
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | Merck Index | ||
|
555-30-6
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
M4R0H12F6M
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
DB00968
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
169916
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
METHYLDOPA
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY | |||
|
61058
Created by
admin on Fri Dec 15 15:57:41 GMT 2023 , Edited by admin on Fri Dec 15 15:57:41 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SOLVATE->ANHYDROUS | |||
|
TARGET -> INHIBITOR | |||
|
SALT/SOLVATE -> PARENT | |||
|
SUBSTANCE->BASIS OF STRENGTH |
Related Record | Type | Details | ||
---|---|---|---|---|
|
METABOLITE -> PARENT |
ACTIVE IN RATS
|
||
|
METABOLITE -> PARENT |
URINE
|
||
|
PARENT -> METABOLITE |
URINE
|
||
|
METABOLITE -> PARENT |
URINE
|
||
|
METABOLITE -> PARENT | |||
|
METABOLITE -> PARENT |
URINE
|
||
|
METABOLITE -> PARENT |
Approximately 70 percent of the drug which is absorbed is excreted in the urine as methyldopa and its mono-0-sulfate conjugate
MAJOR
PLASMA; URINE
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |