Ivabradine (CORLANOR®) is a hyperpolarization-activated cyclic nucleotide-gated channel blocker that reduces the spontaneous pacemaker activity of the cardiac sinus node by selectively inhibiting the If-current, resulting in heart rate reduction at concentrations that do not affect other cardiac ionic currents. Specific heart-rate lowering with ivabradine (CORLANOR®) reduces myocardial oxygen demand, simultaneously improving oxygen supply. It has no negative inotropic or lusitropic effects, preserving ventricular contractility, and does not change any major electrophysiological parameters unrelated to heart rate.

N-Demethyl Ivabradine Hydrochloride is an active metabolite of Ivabradine. Ivabradine protects myocardium in acute ischemic conditions and has favorably sustained remo- deling properties in the long term. N-dealkylated metabolite has also been shown to decrease heart rate in pre-clinical studies when administered to dogs