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Search results for cedazuridine in Any Name (approximate match)
Showing 1 - 1 of 1 results
Status:
US Approved Rx
(2020)
Source:
NDA212576
(2020)
Source URL:
First approved in 2020
Source:
NDA212576
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Cedazuridine is a specific cytidine deaminase (CDA) inhibitor that was approved in combination with decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS). It is known that decitabine is rapidly metabolized by CDA prior to reaching systemic circulation when administered orally. Thus, cedazuridine by inhibition of CDA increases systemic exposure of decitabine.