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Search results for "ORPHAN DRUG|Designated|Treatment of anal cancer" in comments (approximate match)
Showing 1 - 4 of 4 results
Status:
US Approved Rx
(1978)
Source:
NDA018057
(1978)
Source URL:
First approved in 1978
Source:
NDA018057
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Platinous chloride is used as a catalyst in organic synthesis. The salt is insoluble in water.
Status:
US Approved Rx
(2023)
Source:
BLA761334
(2023)
Source URL:
First approved in 2023
Source:
BLA761334
Source URL:
Class:
PROTEIN
Status:
US Approved Rx
(2014)
Source:
BLA125554
(2014)
Source URL:
First approved in 2014
Source:
BLA125554
Source URL:
Class:
PROTEIN
Status:
Investigational
Source:
NCT04032080: Phase 2 Interventional Completed Triple Negative Breast Cancer
(2019)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
LY2606368 (Prexasertib) is a small-molecule Chk-1 inhibitors invented by Array and being developed by Eli Lilly and Company. Lilly is responsible for all clinical development and commercialization activities. LY2606368 is advancing in Phase 2 clinical trials for cancer. Prexasertib preferentially binds to and inhibits CHK1 and, to a lesser extent, inhibits CHK2. Chk-1 is a protein kinase that regulates the tumor cell's response to DNA damage often caused by treatment with chemotherapy. In response to DNA damage, Chk-1 blocks cell cycle progression in order to allow for repair of damaged DNA, thereby limiting the efficacy of chemotherapeutic agents. Inhibiting Chk-1 in combination with chemotherapy can enhance tumor cell death by preventing these cells from recovering from DNA damage.
