U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2Cl.Pt.2H3N
Molecular Weight 300.051
Optical Activity NONE
Additional Stereochemistry Yes
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0
Stereo Comments SP-4-2

SHOW SMILES / InChI
Structure of CISPLATIN

SMILES

N.N.[Cl-].[Cl-].[Pt++]

InChI

InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L
InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

HIDE SMILES / InChI

Description

There is no available sources on the medical use of platinum iodide. The salt is insoluble.

CNS Activity

CNS Non-penetrant
1,014

Originator

Peyrone, M.
4

Approval Year

1978
87

Targets

Primary TargetPharmacologyConditionPotency
DNA
278
Crosslinking Agent
81

Conditions

ConditionModalityTargetsHighest PhaseProduct
Metastatic testicular tumors
4
 Primary
Approved
8,429
CISPLATIN
Metastatic ovarian tumors
4
 Primary
Approved
8,429
CISPLATIN
Advanced bladder cancer
4
 Primary
Approved
8,429
CISPLATIN
Non-small cell lung cancer
206
 Primary
Phase IV
63
CISPLATIN

PubMed

Patents

WO2017059434
4

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
ACTIVE MOIETY
Structure of CISPLATIN
METABOLITE ACTIVE (PRODRUG)
Structure of MONOHYDROXYCISPLATIN
METABOLITE ACTIVE (PRODRUG)
Structure of MONOAQUACISPLATINUM
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966