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Search results for "EU ORPHAN DRUG|Positive|Treatment of non-infectious uveitis" in comments (approximate match)

Showing 1 - 4 of 4 results

VOCLOSPORIN

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2PN063X6B1

Status:

US Approved Rx (2021)

First approved in 2021

Class (Stereo):

CHEMICAL (ABSOLUTE)

Voclosporin (trans-ISA247) is a Cyclosporin A derivative and immunosuppressive compound currently being investigated for the treatment of psoriasis, lupus nephritis and for the prevention of organ rejection in kidney transplant patients. An animal st...

FLUOCINOLONE ACETONIDE

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0CD5FD6S2M

Status:

US Approved Rx (1994)

First approved in 1961

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Conditions:

Fluocinolone Acetonide is a corticosteroid that binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid respo...

nse elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. Cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Like other glucocorticoid agents Fluocinolone acetonide acts as a physiological antagonist to insulin by decreasing glycogenesis (formation of glycogen). It also promotes the breakdown of lipids (lipolysis), and proteins, leading to the mobilization of extrahepatic amino acids and ketone bodies. This leads to increased circulating glucose concentrations (in the blood). There is also decreased glycogen formation in the liver. Fluocinolone Acetonide is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also for the treatment of chronic non-infectious uveitis affecting the posterior segment of the eye (Retisert). Preparations containing Fluocinolone Acetonide were first marketed under the name Synalar.

TRIAMCINOLONE ACETONIDE

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F446C597KA

Status:

US Approved Rx (2017)

First approved in 1958

Class (Stereo):

CHEMICAL (ABSOLUTE)

Conditions:

Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, and to relieve the discomfort of mouth sores. In nasal spray form, it is used to treat allergic rhinitis. It is a more potent derivative of triamcinolone, a...

3-((2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL)CARBAMOYL)THIOPHENE-2-CARBOXYLIC ACID

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02M19CUK9X

Status:

Designated

Class (Stereo):

CHEMICAL (ACHIRAL)

Development Status

Primary Target

Highest Phase

Approval Year

Condition

Treatment Modality

Originator

Substance Class

Code System

ATC Level 1

ATC Level 2

ATC Level 3

ATC Level 4

Substance Form

Search results for "EU ORPHAN DRUG|Positive|Treatment of non-infectious uveitis" in comments (approximate match)

VOCLOSPORIN

2PN063X6B1

FLUOCINOLONE ACETONIDE

0CD5FD6S2M

TRIAMCINOLONE ACETONIDE

F446C597KA

3-((2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL)CARBAMOYL)THIOPHENE-2-CARBOXYLIC ACID

02M19CUK9X