Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C63H111N11O12 |
Molecular Weight | 1214.6244 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 12 / 12 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C=C/C(/[H])=C(\[H])/C[C@@]([H])(C)[C@]([H])([C@@]1([H])C(=N[C@@]([H])(CC)C(=O)N(C)CC(=O)N(C)[C@@]([H])(CC(C)C)C(=N[C@@]([H])(C(C)C)C(=O)N(C)[C@@]([H])(CC(C)C)C(=N[C@@]([H])(C)C(=N[C@]([H])(C)C(=O)N(C)[C@@]([H])(CC(C)C)C(=O)N(C)[C@@]([H])(CC(C)C)C(=O)N(C)[C@@]([H])(C(C)C)C(=O)N1C)O)O)O)O)O
InChI
InChIKey=BICRTLVBTLFLRD-PTWUADNWSA-N
InChI=1S/C63H111N11O12/c1-25-27-28-29-41(15)53(76)52-57(80)66-44(26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27-28,35-48,50-53,76H,1,26,29-34H2,2-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b28-27+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1
Voclosporin (trans-ISA247) is a Cyclosporin A derivative and immunosuppressive compound currently being investigated for the treatment of psoriasis, lupus nephritis and for the prevention of organ rejection in kidney transplant patients. An animal study showed that a lower blood level of Voclosporin was able to produce a greater or similar inhibition of lymphocyte proliferation, expression of T-cell activation surface antigens, and T-cell cytokine production compared to Cyclosporin A. Voclosporin has been shown to be an efficacious and safe immunosuppressant in phase IIb and phase III trials in renal transplant recipients and in plaque psoriasis patients. In clinical trials, Voclosporin added to standard-of-care induction therapy for lupus nephritis increases complete renal remission (CRR) rates, but higher rates of adverse events including death were observed.
Approval Year
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Classification Tree | Code System | Code | ||
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EU-Orphan Drug |
EU/3/12/1085
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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WHO-ATC |
L04AD03
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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NCI_THESAURUS |
C574
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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WHO-VATC |
QL04AD03
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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FDA ORPHAN DRUG |
227806
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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Code System | Code | Type | Description | ||
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M11494
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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PRIMARY | Merck Index | ||
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SUB31127
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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PRIMARY | |||
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515814-01-4
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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PRIMARY | |||
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4366
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admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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PRIMARY | |||
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DB11693
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admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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2PN063X6B1
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admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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C152902
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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VOCLOSPORIN
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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8889
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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CHEMBL2218919
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admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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6918486
Created by
admin on Sat Jun 26 15:42:26 UTC 2021 , Edited by admin on Sat Jun 26 15:42:26 UTC 2021
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ACTIVE MOIETY